The Clinical Research and Latest Application of Genomic Assays in Early-Stage Breast Cancer
文献类型：期刊论文
| 作者 | Chen, Keyu1,2; Wu, Jiayi1,2; Fang, Ziru1,2; Shao, Xiying2; Wang, Xiaojia2 |
| 刊名 | TECHNOLOGY IN CANCER RESEARCH & TREATMENT
 |
| 出版日期 | 2022-09-01 |
| 卷号 | 21 |
| 关键词 | early-stage breast cancer genomic expression profiles Oncotype DX MammaPrint RecurIndex prediction tools |
| ISSN号 | 1533-0346 |
| DOI | 10.1177/15330338221117402 |
| 通讯作者 | Wang, Xiaojia(wxiaojia0803@163.com) |
| 英文摘要 | Breast cancer is a kind of malignant tumor that seriously endangers women's life and health. Once diagnosed, most patients will receive a combination of treatments to achieve a cure. However, breast cancer is a heterogeneous disease. Even with the same clinical stage and pathological features, its response to treatment and postoperative recurrence risk may still be completely different. With the advent of genomic assay, some patients with early-stage breast cancer who originally needed treatment can still achieve long-term disease-free survival without adjuvant chemotherapy, so as to achieve personalized and accurate treatment mode to a certain extent. In this paper, we reviewed the 5 most widely used and studied genomic panel technologies in breast cancer, namely Oncotype DX, MammaPrint, RecurIndex, PAM50, and EndoPredict, according to accessibility and availability. Based on the results of the completed or ongoing clinical studies, we summarized the origin, applicable population, and clinical efficacy of each detection method, and discussed the potential development prospect of detection technology in the future. |
| WOS关键词 | 21-GENE RECURRENCE SCORE ; LATE DISTANT RECURRENCE ; CARCINOMA IN-SITU ; PAM50 RISK ; GENE-EXPRESSION ; LOCOREGIONAL RECURRENCE ; POSTMENOPAUSAL WOMEN ; INTRINSIC SUBTYPES ; ENDOCRINE THERAPY ; NEOADJUVANT CHEMOTHERAPY |
| 资助项目 | National Key research and development program/International cooperation in science and technology innovation[2019YFE0196500] ; Key research and development projects in Zhejiang Province/International cooperation technology research and development and demonstration promotion projects[2020C04012] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000856112700001 |
| 出版者 | SAGE PUBLICATIONS INC |
| 资助机构 | National Key research and development program/International cooperation in science and technology innovation ; Key research and development projects in Zhejiang Province/International cooperation technology research and development and demonstration promotion projects |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/128980]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Xiaojia |
| 作者单位 | 1.Zhejiang Chinese Med Univ, Hangzhou, Zhejiang, Peoples R China 2.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Canc Hosp,Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Keyu,Wu, Jiayi,Fang, Ziru,et al. The Clinical Research and Latest Application of Genomic Assays in Early-Stage Breast Cancer[J]. TECHNOLOGY IN CANCER RESEARCH & TREATMENT,2022,21. |
| APA | Chen, Keyu,Wu, Jiayi,Fang, Ziru,Shao, Xiying,&Wang, Xiaojia.(2022).The Clinical Research and Latest Application of Genomic Assays in Early-Stage Breast Cancer.TECHNOLOGY IN CANCER RESEARCH & TREATMENT,21. |
| MLA | Chen, Keyu,et al."The Clinical Research and Latest Application of Genomic Assays in Early-Stage Breast Cancer".TECHNOLOGY IN CANCER RESEARCH & TREATMENT 21(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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