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Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy

文献类型：期刊论文

作者Zhang, Pengge2; Zhou, Zhixuan3; Long, Wen4; Yan, Yuping2; Li, Youshan2; Fu, Ting1,2; Liu, Yanlan2; Zhao, Zilong2; Tan, Weihong1,2,5,6; Stang, Peter J.3
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
出版日期2022-05-17
卷号119
关键词self-assembly supramolecular coordination complex combination chemotherapy targeted cancer therapy drug delivery
ISSN号0027-8424
DOI10.1073/pnas.2202255119
通讯作者Zhao, Zilong(zlzhao@hnu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn) ; Stang, Peter J.(stang@chem.utah.edu)
英文摘要Combination chemotherapy, which involves the simultaneous use of multiple anticancer drugs in adequate combinations to disrupt multiple mechanisms associated with tumor growth, has shown advantages in enhanced therapeutic efficacy and lower systemic toxicity relative to monotherapy. Herein, we employed coordination-driven self-assembly to construct discrete Pt(II) metallacycles as monodisperse, modular platforms for combining camptothecin and combretastatin A4, two chemotherapy agents with a disparate mechanism of action, in precise arrangements for combination chemotherapy. Formulation of the drug-loaded metallacycles with folic acid-functionalized amphiphilic diblock copolymers furnished nanoparticles with good solubility and stability in physiological conditions. Folic acids on the surface of the nanoparticles promote their internalization into cancer cells. The intracellular reductive environment of cancer cells induces the release of the drug molecules at an exact 1:1 ratio, leading to a synergistic anticancer efficacy. In vivo studies on tumor-bearing mice demonstrated the favorable therapeutic outcome and minimal side effects of the combination chemotherapy approach based on a self-assembled metallacycle.
WOS关键词DRUG ; CAGES ; FUNCTIONALIZATION ; FLUORESCENCE ; METALLACAGES ; DELIVERY ; PRODRUG
资助项目National Key Research and Development Program[2021YFA0910000] ; National Natural Science Foundation of China[21974040] ; National Natural Science Foundation of China[22177028]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000854008900012
出版者NATL ACAD SCIENCES
资助机构National Key Research and Development Program ; National Natural Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/128998]  
专题中国科学院合肥物质科学研究院
通讯作者Zhao, Zilong; Tan, Weihong; Stang, Peter J.
作者单位1.Chinese Acad Sci, Zhejiang Canc Hosp, Univ Chinese Acad Sci, Canc Hosp,Hangzhou Inst Med HIM, Hangzhou 310022, Peoples R China
2.Hunan Univ, Coll Chem & Chem Engn, Aptamer Engn Ctr Hunan Prov, Mol Sci & Biomed Lab MBL,State Key Lab Chemo Bios, Changsha 410082, Peoples R China
3.Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA
4.Hunan Normal Univ, Dept Chem & Chem Engn, Changsha 410081, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med IMM, Shanghai 200240, Peoples R China
6.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Pengge,Zhou, Zhixuan,Long, Wen,et al. Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2022,119.
APA Zhang, Pengge.,Zhou, Zhixuan.,Long, Wen.,Yan, Yuping.,Li, Youshan.,...&Stang, Peter J..(2022).Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,119.
MLA Zhang, Pengge,et al."Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 119(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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