The pathogenesis of organ fibrosis: Focus on necroptosis
文献类型：期刊论文
| 作者 | Hao, Min2; Han, Xin2 ; Yao, Zhouhui2; Zhang, Han3; Zhao, Mengting2; Peng, Mengyun2; Wang, Kuilong2; Shan, Qiyuan2; Sang, Xianan2; Wu, Xin2
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| 刊名 | BRITISH JOURNAL OF PHARMACOLOGY
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| 出版日期 | 2022-10-05 |
| ISSN号 | 0007-1188 |
| 关键词 | liver fibrosis lung fibrosis MLKL necroptosis RIPK1 3 tissue fibrosis |
| DOI | 10.1111/bph.15952 |
| 通讯作者 | Cao, Gang(caogang33@163.com) |
| 英文摘要 | Fibrosis is a common process of tissue repair response to multiple injuries in all chronic progressive diseases, which features with excessive deposition of extracellular matrix. Fibrosis can occur in all organs and tends to be nonreversible with the progress of the disease. Different cells types in different organs are involved in the occurrence and development of fibrosis, that is, hepatic stellate cells, pancreatic stellate cells, fibroblasts and myofibroblasts. Various types of programmed cell death, including apoptosis, autophagy, ferroptosis and necroptosis, are closely related to organ fibrosis. Among these programmed cell death types, necroptosis, an emerging regulated cell death type, is regarded as a huge potential target to ameliorate organ fibrosis. In this review, we summarize the role of necroptosis signalling in organ fibrosis and collate the small molecule compounds targeting necroptosis. In addition, we discuss the potential challenges, opportunities and open questions in using necroptosis signalling as a potential target for antifibrotic therapies. |
| WOS关键词 | PROTEIN-KINASE 1 ; CELL-DEATH ; CONCISE GUIDE ; MEDIATES NECROPTOSIS ; OXIDATIVE STRESS ; RIP3 ; MECHANISMS ; NECROSIS ; COMPLEX ; MLKL |
| 资助项目 | National Natural Science Foundation of China[81922073] ; National Natural Science Foundation of China[81973481] ; National Natural Science Foundation of China[82003948] ; Zhejiang Provincial Natural Science Foundation of China[LQ21H280002] ; Zhejiang Provincial Natural Science Foundation of China[LZ22H280001] ; Basic Public Welfare Research Project in Zhejiang province[LGF18H280003] ; Zhejiang Traditional Chinese Medicine Science and Technology Plan[2021ZB084] ; Zhejiang Traditional Chinese Medicine Science and Technology Plan[2021ZZ009] ; Zhejiang Chinese Medicine University School-level Scientific Research Fund for Talents[2020ZR14] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000863933200001 |
| 资助机构 | National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Basic Public Welfare Research Project in Zhejiang province ; Zhejiang Traditional Chinese Medicine Science and Technology Plan ; Zhejiang Chinese Medicine University School-level Scientific Research Fund for Talents |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/129079]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Cao, Gang |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China 2.Zhejiang Chinese Med Univ, Sch Pharm, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China 3.Zhejiang Chinese Med Univ, Clin Med Coll 3, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hao, Min,Han, Xin,Yao, Zhouhui,et al. The pathogenesis of organ fibrosis: Focus on necroptosis[J]. BRITISH JOURNAL OF PHARMACOLOGY,2022. |
| APA | Hao, Min.,Han, Xin.,Yao, Zhouhui.,Zhang, Han.,Zhao, Mengting.,...&Cao, Gang.(2022).The pathogenesis of organ fibrosis: Focus on necroptosis.BRITISH JOURNAL OF PHARMACOLOGY. |
| MLA | Hao, Min,et al."The pathogenesis of organ fibrosis: Focus on necroptosis".BRITISH JOURNAL OF PHARMACOLOGY (2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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