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Curcumin nanocrystals with tunable surface zeta potential: Preparation, characterization and antibacterial study

文献类型：期刊论文

作者Zong, Rui4; Ruan, Hainan4; Zhu, Wenzheng5; Zhang, Peng4; Feng, Zhaojun4; Liu, Chanmin4; Fan, Shaohua4; Liang, Huamin1,2,3,6; Li, Jun4
刊名JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
出版日期2022-10-01
卷号76
ISSN号1773-2247
关键词Nanocrystals Curcumin Antibacterial activity Surface charge Zeta potential
DOI10.1016/j.jddst.2022.103771
通讯作者Fan, Shaohua(fshfly@jsnu.edu.cn) ; Liang, Huamin(lianghm@hfcas.ac.cn) ; Li, Jun(lijun@jsnu.edu.cn)
英文摘要Curcumin (CUR) is a natural polyphenol with broad-spectrum antimicrobial efficacy, however, its use has been limited by low water solubility and poor stability. The aim of this study was to develop CUR nanocrystals (NCs) to improve its water solubility and stability, and investigate the effect of surface charge on its antibacterial activity. CUR NCs were prepared with different ratios of Pluronic F127 (F127) and hexadecyl trimethyl ammonium bromide (CTAB) as stabilizers to achieve tunable surface charge. The mean particle sizes of CUR NCs were around 150 nm, and zeta potentials were varied from-16.7 to 36.5 mV. Solubility and stability of CUR were significantly enhanced by processing into NCs. In vitro dissolution test showed that the dissolution rate of CUR NC was significantly higher than free CUR. Compared with free CUR, CUR NCs displayed low cytotoxicity against normal human kidney-2 cells. Moreover, comprehensive experiments (MIC, MBC, zone of inhibition and colony counting method) all demonstrate that CUR NCs with high positive surface charge exhibited excellent antibacterial activity than free CUR against E. coli and S. aureus, and SEM images showed that CUR NCs could destroy the surface of the bacteria cell to enhance the antibacterial activity. The overall results suggest that the CUR NC may be a promising antibacterial agent for pharmaceutical application.
WOS关键词ANTIINFLAMMATORY PROPERTIES ; ANTICANCER ; ANTIOXIDANT ; DELIVERY ; SYSTEM
资助项目Natural Science Foundation of Jiangsu Normal University[16XLR046] ; Postgraduate Research & Practice Innovation Program of Jiangsu Province[KYCX22_2808] ; Pri-ority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Leading Talent Program of Hefei[2018-1-006]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:000860503400006
资助机构Natural Science Foundation of Jiangsu Normal University ; Postgraduate Research & Practice Innovation Program of Jiangsu Province ; Pri-ority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Leading Talent Program of Hefei
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/129169]  
专题中国科学院合肥物质科学研究院
通讯作者Fan, Shaohua; Liang, Huamin; Li, Jun
作者单位1.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China
2.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China
3.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Hefei 230031, Peoples R China
4.Jiangsu Normal Univ, Sch Life Sci, Xuzhou 221116, Jiangsu, Peoples R China
5.Jiangsu Normal Univ, CW CHU Coll, Xuzhou 221116, Jiangsu, Peoples R China
6.Chinese Acad Sci, Inst Technol Innovat, Hefei Inst Phys Sci, Precis Targeted Therapy Discovery Ctr, Hefei 230088, Peoples R China
推荐引用方式
GB/T 7714		 Zong, Rui,Ruan, Hainan,Zhu, Wenzheng,et al. Curcumin nanocrystals with tunable surface zeta potential: Preparation, characterization and antibacterial study[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2022,76.
APA Zong, Rui.,Ruan, Hainan.,Zhu, Wenzheng.,Zhang, Peng.,Feng, Zhaojun.,...&Li, Jun.(2022).Curcumin nanocrystals with tunable surface zeta potential: Preparation, characterization and antibacterial study.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,76.
MLA Zong, Rui,et al."Curcumin nanocrystals with tunable surface zeta potential: Preparation, characterization and antibacterial study".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 76(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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