A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s
文献类型：期刊论文
| 作者 | Song, Mengjiao2; Dong, Shiming2; Zhang, Xiangfei1,3; Dai, Yumin2; Zhang, Xin1,3 ; Shen, Yidong2
|
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2022-09-27 |
| 卷号 | 12 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-022-20647-0 |
| 通讯作者 | Shen, Yidong(yidong.shen@sibcb.ac.cn) |
| 英文摘要 | Ageing is co-regulated by genetic and environmental factors. Life on earth lives and evolves in a mild geomagnetic field. Yet, the biological effects of a moderate magnetic field on ageing and the underlying genetic mechanisms remain barely unknown. Here, we report that a moderate static magnetic field (SMF) extends the lifespan of Caenorhabditis elegans, a well-established model organism in ageing research. Consistently, the SMF-treated worms show improved motility and mitochondrial function when aged. We identified from the transcriptomic changes upon SMF treatment that the upregulation of three cytochrome P450 genes are required for SMF-induced longevity. Our findings thus reveal that proper SMF treatment could promote longevity through the well-conserved cytochrome P450 enzymes. |
| WOS关键词 | LIFE-SPAN ; MITOCHONDRIAL ; METABOLISM ; GENETICS ; ACID |
| 资助项目 | National Natural Science Foundation of China[U21A20148] ; Heye Health Technology Inc. |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | NATURE PORTFOLIO |
| WOS记录号 | WOS:000860850600007 |
| 资助机构 | National Natural Science Foundation of China ; Heye Health Technology Inc. |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/129185]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Shen, Yidong |
| 作者单位 | 1.Univ Sci & Technol China, Sci Isl Branch Grad Sch, Hefei, Peoples R China 2.Chinese Acad Sci, Innovat Ctr Cell Signaling Network, Univ Chinese Acad Sci,Shanghai Inst Biochem & Cel, CAS Ctr Excellence Mol Cell Sci,State Key Lab Cel, 320 Yueyang Rd, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Mengjiao,Dong, Shiming,Zhang, Xiangfei,et al. A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s[J]. SCIENTIFIC REPORTS,2022,12. |
| APA | Song, Mengjiao,Dong, Shiming,Zhang, Xiangfei,Dai, Yumin,Zhang, Xin,&Shen, Yidong.(2022).A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s.SCIENTIFIC REPORTS,12. |
| MLA | Song, Mengjiao,et al."A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s".SCIENTIFIC REPORTS 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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