Cost-Effectiveness of Lung Cancer Screening Using Low-Dose Computed Tomography Based on Start Age and Interval in China: Modeling Study
文献类型：期刊论文
| 作者 | Zhao, Zixuan4; Du, Lingbin1; Li, Yuanyuan3; Wang, Le1; Wang, Youqing1; Yang, Yi4; Dong, Hengjin2,4 |
| 刊名 | JMIR PUBLIC HEALTH AND SURVEILLANCE
 |
| 出版日期 | 2022-07-01 |
| 卷号 | 8 |
| ISSN号 | 2369-2960 |
| 关键词 | cost-effectiveness analysis low-dose computed tomography screening lung cancer China |
| DOI | 10.2196/36425 |
| 通讯作者 | Dong, Hengjin(donghj@zju.edu.cn) |
| 英文摘要 | Background: Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer-related death in China. The effectiveness of screening for lung cancer has been reported to reduce lung cancer-specific and overall mortality, although the cost-effectiveness, optimal start age, and screening interval remain unclear. Objective: This study aimed to assess the cost-effectiveness of lung cancer screening among heavy smokers in China by incorporating start age and screening interval. Methods: A Markov state-transition model was used to assess the cost-effectiveness of a lung cancer screening program in China. The evaluated screening strategies were based on a screening start age of 50-74 years and a screening interval of once or annually. Transition probabilities were obtained from the literature and validated, while cost parameters were derived from databases of local medical insurance bureaus. A societal perspective was adopted. The outputs of the model included costs, quality-adjusted life years (QALYs), and lung cancer-specific mortality, with future costs and outcomes discounted by 5%. A currency exchange rate of 1 CNY=0.1557 USD is applicable. The incremental cost-effectiveness ratio (ICER) was calculated for different screening strategies relative to nonscreening. Results: The proposed model suggested that screening led to a gain of 0.001-0.042 QALYs per person as compared with the findings in the nonscreening cohort. Meanwhile, one-time and annual screenings were associated with reductions in lung cancer-related mortality of 0.004%-1.171% and 6.189%-15.819%, respectively. The ICER ranged from 119,974.08 to 614,167.75 CNY per QALY gained relative to nonscreening. Using the World Health Organization threshold of 212,676 CNY per QALY gained, annual screening from a start age of 55 years and one-time screening from the age of 65 years can be considered as cost-effective in China. Deterministic and probabilistic sensitivity analyses were conducted. Conclusions: This economic evaluation revealed that a population-based lung cancer screening program in China for heavy smokers using low-dose computed tomography was cost-effective for annual screening of smokers aged 55-74 years and one-time screening of those aged 65-74 years. Moreover, annual lung cancer screening should be promoted in China to realize the benefits of a guideline-recommended screening program. |
| WOS关键词 | UTILITY ; STAGE ; RISK |
| WOS研究方向 | Public, Environmental & Occupational Health |
| 语种 | 英语 |
| 出版者 | JMIR PUBLICATIONS, INC |
| WOS记录号 | WOS:000862466000007 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/129291]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Dong, Hengjin |
| 作者单位 | 1.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Dept Canc Prevent, Hangzhou, Peoples R China 2.Zhejiang Univ, Affiliated Hosp 4, Sch Med, Dept Sci & Educ, Yi Wu, Peoples R China 3.Hangzhou Ninth Peoples Hosp, Dept Sci & Educ, Hangzhou, Peoples R China 4.Zhejiang Univ, Sch Med, Ctr Hlth Policy Studies, Sch Publ Hlth, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Zixuan,Du, Lingbin,Li, Yuanyuan,et al. Cost-Effectiveness of Lung Cancer Screening Using Low-Dose Computed Tomography Based on Start Age and Interval in China: Modeling Study[J]. JMIR PUBLIC HEALTH AND SURVEILLANCE,2022,8. |
| APA | Zhao, Zixuan.,Du, Lingbin.,Li, Yuanyuan.,Wang, Le.,Wang, Youqing.,...&Dong, Hengjin.(2022).Cost-Effectiveness of Lung Cancer Screening Using Low-Dose Computed Tomography Based on Start Age and Interval in China: Modeling Study.JMIR PUBLIC HEALTH AND SURVEILLANCE,8. |
| MLA | Zhao, Zixuan,et al."Cost-Effectiveness of Lung Cancer Screening Using Low-Dose Computed Tomography Based on Start Age and Interval in China: Modeling Study".JMIR PUBLIC HEALTH AND SURVEILLANCE 8(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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