Influence of Dehydroxymethylepoxyquinomicin on Radiosensitivity of Thyroid Carcinoma TPC-1 Cells
文献类型：期刊论文
| 作者 | Liu, Jie2; Cai, Hu1; Yi, Heqing2; Li, Xin2 ; Peng, Yunsong3; Li, Linfa2
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| 刊名 | JOURNAL OF ONCOLOGY
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| 出版日期 | 2022-09-30 |
| 卷号 | 2022 |
| ISSN号 | 1687-8450 |
| DOI | 10.1155/2022/5026308 |
| 通讯作者 | Li, Linfa(pet-ct001@163.com) |
| 英文摘要 | Objective. To investigate the influence of dehydroxymethylepoxyquinomicin (DHMEQ), an NF-kappa B inhibitor, on radiosensitivity of thyroid carcinoma (TC) TPC-1 cells. Methods. The isolation of CDl33 positive cells (CD133(+) TPC-1) and negative cells (CD133(-) TPC-1) from TPC-1 cells used immunomagnetic bead sorting. After verification of the toxicity of DHMEQ to cells by MTT and cell cloning assays, the cells were divided into four groups, of which three groups were intervened by DHMEQ, I-131 radiation, and DHMEQ +I-131 radiation, respectively, while the fourth group was used as a control without treatment. Alterations in cell growth, apoptosis, and cell cycle were observed. Results. DHMEQ had certain toxic effects on TPC-1 cells, with an IC50 of 38.57 mu g/mL (P < 0.05). DHMEQ inhibited CD133(+) and CD133- TPC-1 proliferation and their clonogenesis after irradiation. DHMEQ + radiation contributed to a growth inhibition rate and an apoptosis rate higher than either or them alone (P < 0.05), with a more significant effect on CD133(-) TPC-1 than CD133+ TPC-1 under the same treatment conditions (P < 0.05). Conclusion. DHEMQ can increase the radiosensitivity of TC cells to I-131, inhibit tumor cell growth, and promote apoptosis. However, its effect is less significant on CD133(+) TPC-1 compared with CD133(-) TPC-1, which may be related to the stem cell-like properties of CD133(+) cells. In the future, the application of DHMEQ in TC 131I radiotherapy will effectively improve the clinical effect of patients. |
| WOS关键词 | FACTOR-KAPPA-B ; THERAPEUTIC TARGET ; PROGRESSION ; APOPTOSIS ; INHIBITOR |
| 资助项目 | Zhejiang medical and health science and technology project ; National Natural Science Foundation of China ; Zhejiang Provincial Medical Health Science and Technology Project ; Zhejiang Provincial Traditional Chinese Medicine Project ; Natural Science Foundation of Zhejiang Province ; [2019KY045] ; [81903982] ; [2018KY296] ; [2016ZB019] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000868325800006 |
| 出版者 | HINDAWI LTD |
| 资助机构 | Zhejiang medical and health science and technology project ; National Natural Science Foundation of China ; Zhejiang Provincial Medical Health Science and Technology Project ; Zhejiang Provincial Traditional Chinese Medicine Project ; Natural Science Foundation of Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/129422]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Li, Linfa |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc Chinese, Dept Integrated Tradit Chinese & Western Med,Canc, Hangzhou 310022, Zhejiang, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc Chinese, Dept Nucl Med,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc Chinese, Dept Pharm,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jie,Cai, Hu,Yi, Heqing,et al. Influence of Dehydroxymethylepoxyquinomicin on Radiosensitivity of Thyroid Carcinoma TPC-1 Cells[J]. JOURNAL OF ONCOLOGY,2022,2022. |
| APA | Liu, Jie,Cai, Hu,Yi, Heqing,Li, Xin,Peng, Yunsong,&Li, Linfa.(2022).Influence of Dehydroxymethylepoxyquinomicin on Radiosensitivity of Thyroid Carcinoma TPC-1 Cells.JOURNAL OF ONCOLOGY,2022. |
| MLA | Liu, Jie,et al."Influence of Dehydroxymethylepoxyquinomicin on Radiosensitivity of Thyroid Carcinoma TPC-1 Cells".JOURNAL OF ONCOLOGY 2022(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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