Whether individualized dose escalation should be recommended for lymph nodes with different sizes in the definitive radiotherapy of cervical cancer?
文献类型：期刊论文
| 作者 | Lv, Xiaojuan1,3; Rao, Huiting2,3; Feng, Tao2,3; Wu, Chufan2,3; Lou, Hanmei1,2,3 |
| 刊名 | RADIATION ONCOLOGY
 |
| 出版日期 | 2022-10-20 |
| 卷号 | 17 |
| 关键词 | Radiotherapy Dose escalation Lymph node Uterine cervical neoplasms |
| DOI | 10.1186/s13014-022-02132-0 |
| 通讯作者 | Lou, Hanmei(louhm@zjcc.org.cn) |
| 英文摘要 | Background and purpose Dose escalation for positive node maybe improve the regional control of patients with node-positive cervical cancer, but the optimal dose for nodes of different sizes remains controversial. The purpose of this study was to explore the individualized dose escalation for lymph nodes (LNs) with different sizes in the definitive radiotherapy of cervical cancer. Methods A total of 1002 cervical cancer patients with the International Federation of Gynecology and Obstetrics (FIGO 2009) stage IB1-IVA, who were treated by definitively radiotherapy between September 2013 and December 2016 were enrolled. All LNs identified by computed tomography/magnetic resonance imaging (CT/MRI) were assigned into three groups according to the short diameters of < 1 cm, 1-2 cm or >= 2 cm at pretreatment. Results In total, 580 patients with 1310 LNs were detected. The nodal control rate in groups of LNs < 1 cm, 1-2 cm and >= 2 cm was 99.4%, 96%, and 75.9%, respectively (P = 0.000). Among LNs < 1 cm, the control, overall survival (OS) and progression-free survival (PFS) rates did not significantly differ among three dose-based groups (<= 50.4 Gy, 50.4-60 Gy, > 60 Gy) (control rate, 99.4% vs. 99.3% vs. 100%, P = 0.647) (5-year OS, 76.2% vs. 79% vs. 81.6%, P = 0.682) (5-year PFS, 74.1% vs. 73.9% vs. 78.9% P = 0.713). Among LNs of 1-2 cm, the control and PFS rates were significantly higher in the group of dose >= 55 Gy than the group of dose < 55 Gy (control rate, 98% vs. 93.6%, P = 0.028) (5-year PFS, 69.6% vs. 56.7%, P = 0.025). However, this did not cause a significant difference for 5-year OS rate (72.6% vs. 68.3%, P = 0.5). Among LNs >= 2 cm, the control, OS, and PFS rates were higher in the group of dose >= 55 Gy than the group of dose < 55 Gy, while no significant difference was found (control rate, 82.1% vs. 63.2%, P = 0.107) (5-year OS, 60.6% vs. 37.5%, P = 0.141) (5-year PFS, 51.5% vs.37.5%, P = 0.232). Conclusions Radiation dose escalation is not necessary for LNs < 1 cm, and dose escalation of 55 Gy is enough for LNs of 1-2 cm. |
| WOS关键词 | GUIDED ADAPTIVE BRACHYTHERAPY ; RADIATION-THERAPY ; BOOST IRRADIATION ; CHEMORADIATION ; METASTASES ; PATTERNS |
| 资助项目 | Zhejiang Province Health Department Foundation, China[2018KY306] ; Zhejiang Province Health Department Foundation, China[2022KY647] |
| WOS研究方向 | Oncology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000870739400001 |
| 出版者 | BMC |
| 资助机构 | Zhejiang Province Health Department Foundation, China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/129456]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Lou, Hanmei |
| 作者单位 | 1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Banshan East Rd 1, Hangzhou 310022, Zhejiang, Peoples R China 2.Zhejiang Chinese Med Univ, Affiliated Coll 2, Binwen Rd 548, Hangzhou 310053, Zhejiang, Peoples R China 3.Univ Chinese Acad Sci, Dept Gynecol Radiat Oncol, Canc Hosp, Zhejiang Canc Hosp, Banshan East Rd 1, Hangzhou 310022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Xiaojuan,Rao, Huiting,Feng, Tao,et al. Whether individualized dose escalation should be recommended for lymph nodes with different sizes in the definitive radiotherapy of cervical cancer?[J]. RADIATION ONCOLOGY,2022,17. |
| APA | Lv, Xiaojuan,Rao, Huiting,Feng, Tao,Wu, Chufan,&Lou, Hanmei.(2022).Whether individualized dose escalation should be recommended for lymph nodes with different sizes in the definitive radiotherapy of cervical cancer?.RADIATION ONCOLOGY,17. |
| MLA | Lv, Xiaojuan,et al."Whether individualized dose escalation should be recommended for lymph nodes with different sizes in the definitive radiotherapy of cervical cancer?".RADIATION ONCOLOGY 17(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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