中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
A multi-institutional study of association of sonographic characteristics with cervical lymph node metastasis in unifocal papillary thyroid carcinoma

文献类型：期刊论文

作者Zhou, Liuhua2; Yao, Jincao1,7; Ou, Di1,7; Li, Mingkui6; Lei, Zhikai5; Wang, Liping1,7; Xu, Dong1,3,4,7
刊名FRONTIERS IN ENDOCRINOLOGY
出版日期2022-09-23
卷号13
关键词ultrasonography thyroid cancer papillary lymphatic metastases imaging TI-RADS category
ISSN号1664-2392
DOI10.3389/fendo.2022.965241
通讯作者Wang, Liping(wanglp@zjcc.org.cn) ; Xu, Dong(xudong@zjcc.org.cn)
英文摘要ObjectivePapillary thyroid carcinoma (PTC) is the most common pathological type of thyroid carcinoma, and is prone to cervical lymph node metastases (CLNM). We aim to evaluate the association between sonographic characteristics of PTC and CLNM before the initial surgery. MethodsClinical information as well as ultrasonographic measurements and characteristics for 2376 patients from three hospitals were acquired in this retrospective cohort study. Univariate and multivariate logistic analysis were performed to predict CLNM in unifocal PTC patients. Receiver operating characteristic (ROC) curve was created to evaluate diagnostic performance. ResultsUnivariate analysis showed that gender, age, maximum tumor diameter and volume, cross-sectional and longitudinal aspect ratio, location, echogenicity, margin, and echogenic foci were independently associated with CLNM metastatic status (P < 0.05). Multivariate logistic analysis showed that gender, age, maximum tumor diameter and volume, cross-sectional aspect ratio (CSAR), location, echogenicity, margin, and echogenic foci were independent correlative factors; CSAR showed a significant difference for PTC2 to predict CLNM. The area under the curve (AUC) of the maximum tumor diameter, tumor volume, margin, and echogenic foci was 0.70, 0.69, 0.65, and 0.70, respectively. The multiple-variable linear regression model was constructed with an AUC of 0.77, a specificity of 73.4%, and a sensitivity of 72.3%. Kruskal-Wallis analysis for positive subgroups, maximum tumor diameter and volume, cross-sectional and longitudinal aspect ratio, margin, and echogenic foci showed statistical significance (P < 0.05). ConclusionsYounger age (< 55 years), male, larger tumor, and echogenic foci were high risk factors for CLNM in patients with unifocal PTC. CSAR had a more effective predictive value for CLNM in patients with larger thyroid tumors. A larger tumor with irregular and punctate echogenic foci was also more prone to the lateral neck, and both central and lateral neck metastasis.
WOS关键词DATA SYSTEM ; US FEATURES ; CANCER ; RISK ; NODULES ; STRATIFICATION ; CALCIFICATION ; RECURRENCE ; ULTRASOUND ; PREDICTION
资助项目National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; [82071946] ; [LSD19H180001]
WOS研究方向Endocrinology & Metabolism
语种英语
WOS记录号WOS:000871794200001
出版者FRONTIERS MEDIA SA
资助机构National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/129460]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Liping; Xu, Dong
作者单位1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China
2.Zhejiang Chinese Med Univ, Hangzhou, Peoples R China
3.Zhejiang Prov Res Ctr Canc Intelligent Diag & Mol, Hangzhou, Peoples R China
4.Key Lab Head & Neck Canc Translat Res Zhejiang Pro, Hangzhou, Peoples R China
5.Hangzhou Canc Hosp, Hangzhou, Peoples R China
6.Zhejiang Xiaoshan Hosp, Hangzhou, Peoples R China
7.Chinese Acad Sci, Institue Basic Med & Canc IBMC, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Liuhua,Yao, Jincao,Ou, Di,et al. A multi-institutional study of association of sonographic characteristics with cervical lymph node metastasis in unifocal papillary thyroid carcinoma[J]. FRONTIERS IN ENDOCRINOLOGY,2022,13.
APA Zhou, Liuhua.,Yao, Jincao.,Ou, Di.,Li, Mingkui.,Lei, Zhikai.,...&Xu, Dong.(2022).A multi-institutional study of association of sonographic characteristics with cervical lymph node metastasis in unifocal papillary thyroid carcinoma.FRONTIERS IN ENDOCRINOLOGY,13.
MLA Zhou, Liuhua,et al."A multi-institutional study of association of sonographic characteristics with cervical lymph node metastasis in unifocal papillary thyroid carcinoma".FRONTIERS IN ENDOCRINOLOGY 13(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。