中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
Baseline anemia predicts a poor prognosis in patients with non-small cell lung cancer with epidermal growth factor receptor mutations: a retrospective study

文献类型：期刊论文

作者Wei, Jingwen1,2; Xiang, Jing1,3; Hao, Yue1,3; Si, Jinfei1,3; Wang, Wenxian4; Li, Fangyin5; Song, Zhengbo1
刊名BMC PULMONARY MEDICINE
出版日期2022-10-17
卷号22
ISSN号1471-2466
关键词Anemia Epidermal growth factor receptor Epidermal growth factor receptor tyrosine kinase inhibitors Non-small cell lung cancer
DOI10.1186/s12890-022-02158-w
通讯作者Li, Fangyin(lify824@126.com) ; Song, Zhengbo(songzb@zjcc.org.cn)
英文摘要Background Anemia is relatively common in cancer patients, and baseline anemia is associated with poor survival in patients with non-small cell lung cancer (NSCLC). However, there is a lack of large-sample studies of patients with NSCLC with epidermal growth factor receptor (EGFR) mutations. Methods We retrospectively analyzed anemia-related data for patients with NSCLC and EGFR mutations who were admitted to Zhejiang Cancer Hospital from January 2013 to June 2019 and treated with targeted therapy. The patients' clinicopathological features were evaluated by chi(2) tests and the relationships between clinical characteristics and prognosis were investigated using Kaplan-Meier and multivariate Cox regression analyses. Results A total of 2,029 patients treated with EGFR-tyrosine kinase inhibitors (TKIs) were finally enrolled in this study, of whom 24.6% had baseline anemia. Patients without baseline anemia had longer median overall survival (OS) than patients with baseline anemia (36.10 vs. 29.10 months, P = 0.001), and patients with grade < 2 anemia had longer median OS than those with grade >= 2 anemia (35.00 vs. 25.10 months, P < 0.001). Multivariate analyses identified baseline anemia as a factor predicting a poor prognosis in terms of OS in patients with EGFR mutations. Conclusions Baseline anemia is a significant factor predicting a poor prognosis in terms of OS in patients with NSCLC and EGFR mutations treated with targeted therapy. A higher grade of baseline anemia may also be related to shorter OS. And a higher risk of EGFR-mutated patients who had received targeted therapy could also be observed.
WOS关键词HEALTH-ORGANIZATION CLASSIFICATION ; SURVIVAL ; TUMOR ; EPIDEMIOLOGY ; INFLAMMATION ; EXPRESSION ; CARCINOMA ; HYPOXIA ; IMPACT ; IRON
资助项目Medical Scientific Research Foundation of Zhejiang Province[2022KY653]
WOS研究方向Respiratory System
语种英语
出版者BMC
WOS记录号WOS:000869249500001
资助机构Medical Scientific Research Foundation of Zhejiang Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/129474]  
专题中国科学院合肥物质科学研究院
通讯作者Li, Fangyin; Song, Zhengbo
作者单位1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Clin Trial, 1 Banshan East Rd, Hangzhou 310022, Peoples R China
2.Wenzhou Med Univ, Wenzhou, Peoples R China
3.Chinese Med Univ, Clin Med Coll Zhejiang 2, Hangzhou, Peoples R China
4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Med Oncol, Hangzhou, Peoples R China
5.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Dept Urol, 1 Banshan East Rd, Hangzhou 310022, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Jingwen,Xiang, Jing,Hao, Yue,et al. Baseline anemia predicts a poor prognosis in patients with non-small cell lung cancer with epidermal growth factor receptor mutations: a retrospective study[J]. BMC PULMONARY MEDICINE,2022,22.
APA Wei, Jingwen.,Xiang, Jing.,Hao, Yue.,Si, Jinfei.,Wang, Wenxian.,...&Song, Zhengbo.(2022).Baseline anemia predicts a poor prognosis in patients with non-small cell lung cancer with epidermal growth factor receptor mutations: a retrospective study.BMC PULMONARY MEDICINE,22.
MLA Wei, Jingwen,et al."Baseline anemia predicts a poor prognosis in patients with non-small cell lung cancer with epidermal growth factor receptor mutations: a retrospective study".BMC PULMONARY MEDICINE 22(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。