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Intracellular Delivery of Micron-Sized Magnetic Particles through a Virus Infection Pathway

文献类型：期刊论文

作者Feng, Xiayi2,3; Gao, Ding2; Jing, Yipeng4,5; Qian, Junchao6; Cui, Zongqiang2; Zhou, Juan2; Zhang, Xian -En1,3,7; Men, Dong2,3
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2022-10-05
ISSN号1944-8244
关键词micron-sized magnetic particles virus-like particles intracellular pathway fluorescence co-localization magnetic resonance imaging
DOI10.1021/acsami.2c11991
通讯作者Zhou, Juan(zhoujuan@wh.iov.cn) ; Zhang, Xian -En(zhangxe@ibp.ac.cn) ; Men, Dong(d.men@wh.iov.cn)
英文摘要Micron-sized magnetic particles (M-MPs) have low toxicity, strong magnetic signals, and long-term retention capability, which are significant advantages for their application in biomedical imaging. Unfortunately, M-MPs are only internalized by few cell types, such as macrophages and phagocytes, and because of this lack of active intracellular delivery, their applications are restricted. The emergence of self-assembled virus-like particles (VLPs) offers a viable approach to drive M-MPs into cells, although the specific mechanism has not been revealed. In this study, we investigated in detail the intracellular pathway of M-MPs mediated by VLPs using a fluorescence co-localization method. The results indicated that the intracellular movement of M-MPs was consistent with the virus infection pathway, specifically caveolae-dependent endocytosis, transportation through microtubules, and accumulation in the endoplasmic reticulum. This study provides experimental support for the active transport of M-MPs into other cell types, thereby further extending their applications.
WOS关键词IRON-OXIDE ; ENDOTHELIAL ACTIVATION ; CELLS ; MICROPARTICLES ; ADVANCEMENTS ; NANO
资助项目Knowledge Innovation Program of Wuhan-Shuguang Project[2022020801020154] ; National Natural Science Foundation of China[21890743] ; National Natural Science Foundation of China[31771098] ; Youth Innovation Promotion Association of CAS[2014308] ; Interdisciplinary Innovation Team of CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29050100]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000870033000001
资助机构Knowledge Innovation Program of Wuhan-Shuguang Project ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of CAS ; Interdisciplinary Innovation Team of CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/129484]  
专题中国科学院合肥物质科学研究院
通讯作者Zhou, Juan; Zhang, Xian -En; Men, Dong
作者单位1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Fac Synthet Biol, Shenzhen 518055, Peoples R China
2.Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan 430071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Henan Univ, Nursing & Hlth Coll, Kaifeng 475004, Peoples R China
5.Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China
6.Chinese Acad Sci, Hefei Canc Hosp, Inst Hlth & Med Technol, Hefei Inst Phys Sci,Anhui Prov Key Lab Med Phys &, Hefei 230031, Peoples R China
7.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Xiayi,Gao, Ding,Jing, Yipeng,et al. Intracellular Delivery of Micron-Sized Magnetic Particles through a Virus Infection Pathway[J]. ACS APPLIED MATERIALS & INTERFACES,2022.
APA Feng, Xiayi.,Gao, Ding.,Jing, Yipeng.,Qian, Junchao.,Cui, Zongqiang.,...&Men, Dong.(2022).Intracellular Delivery of Micron-Sized Magnetic Particles through a Virus Infection Pathway.ACS APPLIED MATERIALS & INTERFACES.
MLA Feng, Xiayi,et al."Intracellular Delivery of Micron-Sized Magnetic Particles through a Virus Infection Pathway".ACS APPLIED MATERIALS & INTERFACES (2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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