GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis
文献类型：期刊论文
| 作者 | Chenggang Zhao3; Huihan Yu3; Xiaoqing Fan3; Wanxiang Niu3; Junqi Fan3; Suling Sun3; Meiting Gong3; Bing Zhao1; Zhiyou Fang3; Xueran Chen3 |
| 刊名 | Oncogenesis
 |
| 卷号 | 11 |
| ISSN号 | 2157-9024 |
| 英文摘要 | Glioblastoma stem cells (GSCs) are a highly tumorigenic cell subgroup of glioblastoma (GBM). Glycogen synthase kinase 3β (GSK3β) is considered a key hub for promoting malignant phenotypes in GBM. However, the functional relationships between GSK3β and GSCs in GBM are unclear. Here, we found that GSK3β was noted as a substrate for ZDHHC4-mediated palmitoylation at the Cys14 residue, which enhanced GBM temozolomide (TMZ) resistance and GSC self-renewal. Clinically, the expression level of ZDHHC4 was upregulated in GBM, which significantly correlated with tumor grade and poor prognosis. The above phenotypes were based on decreasing p- Ser9 and increasing p- Tyr216 by GSK3β palmitoylation, which further activated the enhancer of the zeste homolog 2 (EZH2)–STAT3 pathway. Notably, STAT3 silencing also inhibited ZDHHC4 expression. This study revealed that GSK3β palmitoylation mediated by ZDHHC4 improved the stemness of TMZ-resistant GBM by activating the EZH2–STAT3 signaling axis, providing a new theoretical basis for further understanding the mechanism of TMZ resistance and recurrence after treatment. |
| 语种 | 英语 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/129503]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 作者单位 | 1.安徽医科大学 2.中国科学技术大学 3.?中国科学院合肥物质科学研究院 4.中国科学院合肥物质科学研究院 5.University of Science & Technology of China |
| 推荐引用方式 GB/T 7714 | Chenggang Zhao,Huihan Yu,Xiaoqing Fan,et al. GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis[J]. Oncogenesis,11. |
| APA | Chenggang Zhao.,Huihan Yu.,Xiaoqing Fan.,Wanxiang Niu.,Junqi Fan.,...&Xueran Chen. |
| MLA | Chenggang Zhao,et al."GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2–STAT3 axis".Oncogenesis 11 |
入库方式： OAI收割
来源：合肥物质科学研究院
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