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Decoding the multidimensional signatures of resident and expanded natural killer cells generated from perinatal blood

文献类型：期刊论文

作者Zhang, Leisheng2,3,4,5,6; Liu, Min7; Song, Baoquan8; Miao, Wenjing8; Zhan, Rucai4; Yang, Sijun9; Han, Zhihai9; Cai, Hui2,3; Xu, Xianghong1; Zhao, Yixiao10
刊名AMERICAN JOURNAL OF CANCER RESEARCH
出版日期2022
卷号12
关键词Perinatal blood resident NK cells (rNKs) expanded NK cells (eNKs) biological phenotype transcriptomic signatures
ISSN号2156-6976
通讯作者Zhang, Leisheng(leisheng_zhang@163.com) ; Guo, Tiankang(gtk-2008@163.com) ; Yao, Jun(dentyao@163.com) ; Huang, Qing(huangq@ipp.ac.cn)
英文摘要Natural killer (NK) cells are lymphocytes and play a pivotal role in innate and adaptive immune responses against infections and malignancies. Longitudinal studies have indicated the feasibility of perinatal blood for large-scale NK cell generation, yet the systematic and detailed comparations of the signatures of resident and expanded NK cells (rNKs, eNKs) are largely obscure. Herein, we harvested rNKs from umbilical cord blood (rUC-NKs) and placental blood (rP-NKs) as well as the corresponding eNKs (eUC-NKs, eP-NKs). Furthermore, the biological properties and transcriptomic signatures including cellular subpopulations, cytotoxicity, gene expression profiling, genetic characteristics, signaling pathways and gene set-related biological process were investigated. The enriched rNKs and eNKs exhibited diversity in biomarker expression pattern, and eNKs with higher percentages of NKG2D(+), NKG2A(+), NKp44(+) and NKp46(+) subsets. rNKs or eNKs with different origins showed more similarities in transcriptomic signatures than those with the same origin. Our data revealed multifaceted similarities and differences of the indicated rNKs and pNKs both at the cellular and molecular levels. Our findings provide new references for further dissecting the efficacy and molecular mechanisms of rNKs and eNKs, which will collectively benefit the fundamental and translational studies of NK cell-based immunotherapy.
WOS关键词CANCER-IMMUNOTHERAPY ; TRANSPLANTATION ; THERAPY
资助项目Shandong Provincial Natural Science Foundation[ZR2020QC097] ; Translational Research Grant of NCRCH[2021ZKQA03] ; Science and technology projects of Guizhou Province[QKH-J-ZK[2021]-107] ; Natural Science Foundation of Fujian Province[2020J01649] ; National Natural Science Foundation of China[81330015] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2019PT320005] ; Natural Science Foundation of Hebei Province[H2020206403] ; China Postdoctoral Science Foundation[2019M661033] ; Natural Science Foundation of Tianjin City[19JCQNJC12500] ; Jiangxi Key New Product Incubation Program - Technical Innovation Guidance Program of Shangrao[2020G002] ; Natural Science Foundation of Jiangxi Province[20212BAB216073]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000804191800012
出版者E-CENTURY PUBLISHING CORP
资助机构Shandong Provincial Natural Science Foundation ; Translational Research Grant of NCRCH ; Science and technology projects of Guizhou Province ; Natural Science Foundation of Fujian Province ; National Natural Science Foundation of China ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences ; Natural Science Foundation of Hebei Province ; China Postdoctoral Science Foundation ; Natural Science Foundation of Tianjin City ; Jiangxi Key New Product Incubation Program - Technical Innovation Guidance Program of Shangrao ; Natural Science Foundation of Jiangxi Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/129562]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Leisheng; Guo, Tiankang; Yao, Jun; Huang, Qing
作者单位1.Gansu Prov Hosp, Dept Biotherapy Ctr, Lanzhou 730000, Gansu, Peoples R China
2.Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gans, Lanzhou 730000, Gansu, Peoples R China
3.Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou 730000, Gansu, Peoples R China
4.Shandong First Med Univ, Affiliated Hosp 1, Ctr Cellular Therapies, Jinan 250014, Shandong, Peoples R China
5.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Radiat Technol & Biophys, Hefei 230031, Anhui, Peoples R China
6.Hlth Biotech Tianjin Stem Cell Res Inst Co Ltd, Inst Hlth Biotech, Tianjin 301701, Peoples R China
7.Vet Bur, Dept Agr & Anim Husb Inner Mongolia Autonomous Re, Hohhot 010011, Peoples R China
8.Soochow Univ, Affiliated Hosp 1, Natl Clin Res Ctr Hematol Dis, Suzhou 215006, Jiangsu, Peoples R China
9.Jiangxi Hlth Biotech Stem Cell Technol Co Ltd, Jiangxi Res Ctr Stem Cell Engn, Shangrao 334000, Jiangxi, Peoples R China
10.Northwest Agr & Forestry Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Leisheng,Liu, Min,Song, Baoquan,et al. Decoding the multidimensional signatures of resident and expanded natural killer cells generated from perinatal blood[J]. AMERICAN JOURNAL OF CANCER RESEARCH,2022,12.
APA Zhang, Leisheng.,Liu, Min.,Song, Baoquan.,Miao, Wenjing.,Zhan, Rucai.,...&Huang, Qing.(2022).Decoding the multidimensional signatures of resident and expanded natural killer cells generated from perinatal blood.AMERICAN JOURNAL OF CANCER RESEARCH,12.
MLA Zhang, Leisheng,et al."Decoding the multidimensional signatures of resident and expanded natural killer cells generated from perinatal blood".AMERICAN JOURNAL OF CANCER RESEARCH 12(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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