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Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis

文献类型：期刊论文

作者Balachandran, Yekkuni L.3; Wang, Wei1; Yang, Hongyi4; Tong, Haiyang4; Wang, Lulu4; Liu, Feng1; Chen, Hongsong1; Zhong, Kai4; Liu, Ye2; Jiang, Xingyu3
刊名ACS NANO
出版日期2022-03-21
卷号16
ISSN号1936-0851
关键词iron oxide-dysprosium oxide nanoparticles MRI contrast agent ultrahigh-field MRI liver fibrosis noninvasive detection
DOI10.1021/acsnano.1c10618
通讯作者Wang, Wei(wangwei9934@163.com) ; Jiang, Xingyu(jiang@sustech.edu.cn)
英文摘要Challenges remain in precisely diagnosing the progress of liver fibrosis in a noninvasive way. We here synthesized small (4 nm) heterogeneous iron oxide/dysprosium oxide nanoparticles (IO-DyO NPs) as a contrast agent (CA) for magnetic resonance imaging (MRI) to precisely diagnose liver fibrosis in vivo at both 7.0 and 9.4 T field strength. Our IO-DyO NPs can target the liver and show an increased T-2 relaxivity along with an increase of magnetic field strength. At a ultrahigh magnetic field, IO-DyO NPs can significantly improve spatial/ temporal image resolution and signal-to-noise ratio of the liver and precisely distinguish the early and moderate liver fibrosis stages. Our IO-DyO NP-based MRI diagnosis can exactly match biopsy (a gold standard for liver fibrosis diagnosis in the clinic) but avoid the invasiveness of biopsy. Moreover, our IO-DyO NPs show satisfactory biosafe in vitro and in vivo. This work illustrates an advanced T-2 CA used in ultrahigh-field MRI (UHFMRI) for the precise diagnosis of liver fibrosis via a noninvasive means.
WOS关键词CONTRAST AGENTS ; HEPATIC-FIBROSIS ; SPIN RELAXATION ; T2 RELAXATION ; COLLAGEN ; MRI ; INFLAMMATION ; T1 ; BIOCOMPATIBILITY ; CHALLENGES
资助项目National Key R&D Program of China[2018YFA0902600] ; National Key R&D Program of China[2017YFA0205901] ; National Natural Science Foundation of China[21535001] ; National Natural Science Foundation of China[81730051] ; National Natural Science Foundation of China[21761142006] ; National Natural Science Foundation of China[81501790] ; National Natural Science Foundation of China[21874033] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Chinese Academy of Sciences[121D11KYSB20170026] ; Chinese Academy of Sciences[XDA16020902] ; Tencent Foundation through the XPLORER PRIZE the Leading Medical Talents Program of Health Commission of Yunnan Province[L-2018013] ; Young and Middle-Aged Academic and Technical Leaders Program of Yunnan Province
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000813098400001
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Tencent Foundation through the XPLORER PRIZE the Leading Medical Talents Program of Health Commission of Yunnan Province ; Young and Middle-Aged Academic and Technical Leaders Program of Yunnan Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/129564]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Wei; Jiang, Xingyu
作者单位1.Peking Univ, Peking Univ Peoples Hosp, Hepatol Inst,Beijing Key Lab Hepatitis C & Immuno, Beijing Int Cooperat Base Sci & Technol NAFLD Dia, Beijing 100044, Peoples R China
2.Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biol, Kunming 650000, Yunnan, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Shenzhen 518055, Guangdong, Peoples R China
4.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Balachandran, Yekkuni L.,Wang, Wei,Yang, Hongyi,et al. Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis[J]. ACS NANO,2022,16.
APA Balachandran, Yekkuni L..,Wang, Wei.,Yang, Hongyi.,Tong, Haiyang.,Wang, Lulu.,...&Jiang, Xingyu.(2022).Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis.ACS NANO,16.
MLA Balachandran, Yekkuni L.,et al."Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis".ACS NANO 16(2022).

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来源：合肥物质科学研究院

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