Cold Atmospheric Plasma Inhibits the Proliferation of CAL-62 Cells through the ROS-Mediated PI3K/Akt/mTOR Signaling Pathway
文献类型：期刊论文
| 作者 | Liu, Fang1,2 ; Zhou, Yuanyuan1,2; Song, Wencheng1,3; Wang, Hongzhi1,3
|
| 刊名 | SCIENCE AND TECHNOLOGY OF NUCLEAR INSTALLATIONS
 |
| 出版日期 | 2022-06-08 |
| 卷号 | 2022 |
| ISSN号 | 1687-6075 |
| DOI | 10.1155/2022/3884695 |
| 通讯作者 | Song, Wencheng(wencsong@cmpt.ac.cn) ; Wang, Hongzhi(wanghz@hfcas.ac.cn) |
| 英文摘要 | This study aimed to investigate the inhibitory effects of cold atmospheric plasma (CAP) on anaplastic thyroid cancer cells (CAL-62 cells) and to reveal the molecular mechanism. The effects of CAP on CAL-62 cells were evaluated by cell viability, superoxide dismutase activity, apoptosis, cell cycle, and protein expression level, and the role of reactive oxygen species (ROS) produced by plasma was also investigated. The results showed that CAP dose-dependently inhibited cell viability and promotes cell apoptosis and G2/M arrest by increasing cell ROS levels. The activity of superoxide dismutase (SOD) was enhanced by CAP which indicated that the antioxidant system of the cell was activated. Additionally, the ROS produced by CAP can inhibit CAL-62 cell proliferation by inhibiting the PI3K/Akt/mTOR signaling pathway. Therefore, these findings will provide useful support for the application of CAP for treating anaplastic thyroid cancer. |
| WOS关键词 | APOPTOSIS ; SENSITIVITY ; INVOLVEMENT ; SYSTEM ; INJURY |
| 资助项目 | National Natural Science Foundation of China[21876179] ; National Natural Science Foundation of China[22142007] |
| WOS研究方向 | Nuclear Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000813590800001 |
| 出版者 | HINDAWI LTD |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/129574]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Song, Wencheng; Wang, Hongzhi |
| 作者单位 | 1.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China 2.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China 3.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Fang,Zhou, Yuanyuan,Song, Wencheng,et al. Cold Atmospheric Plasma Inhibits the Proliferation of CAL-62 Cells through the ROS-Mediated PI3K/Akt/mTOR Signaling Pathway[J]. SCIENCE AND TECHNOLOGY OF NUCLEAR INSTALLATIONS,2022,2022. |
| APA | Liu, Fang,Zhou, Yuanyuan,Song, Wencheng,&Wang, Hongzhi.(2022).Cold Atmospheric Plasma Inhibits the Proliferation of CAL-62 Cells through the ROS-Mediated PI3K/Akt/mTOR Signaling Pathway.SCIENCE AND TECHNOLOGY OF NUCLEAR INSTALLATIONS,2022. |
| MLA | Liu, Fang,et al."Cold Atmospheric Plasma Inhibits the Proliferation of CAL-62 Cells through the ROS-Mediated PI3K/Akt/mTOR Signaling Pathway".SCIENCE AND TECHNOLOGY OF NUCLEAR INSTALLATIONS 2022(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。