中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
Prognostic value and clinicopathological correlation of the tumor regression grade in neoadjuvant chemotherapy for gastric adenocarcinoma: a retrospective cohort study

文献类型：期刊论文

作者Wang, Yi2,3,4,5; Xu, Handong2,3,4,5; Hu, Can2,3,4,5; Yu, Pengcheng2,3,4,5; Bao, Zhehan2,3,4,5; Zhang, Yanqiang3,4,5; Zhang, Ruolan2,3,4,5; Zhang, Shengjie3,4,5; Li, Bing6; Aerts, Jean-Marie1
刊名JOURNAL OF GASTROINTESTINAL ONCOLOGY
出版日期2022-06-16
ISSN号2078-6891
DOI10.21037/jgo-22-537
通讯作者Xu, Zhiyuan(xuzy@zjec.org.cn) ; Cheng, Xiangdong(chengxd@zjec.org.cn)
英文摘要Background: Neoadjuvant chemotherapy (NACT) and radical gastrectomy are the gold standard treatment for resectable advanced gastric cancer (GC). However, the prognostic value of the pathological tumor regression grade (TRG) of NACT remains controversial. This retrospective study aimed to investigate the correlation between the TRG after NACT and clinicopathological features as well as its prognostic value in advanced GC. Methods: In total, 551 patients with GC who received NACT combined with surgical resection at the Zhejiang Cancer Hospital from April 2004 to December 2019 were included. The demographic characteristics, treatment response, tumor characteristics, treatment regimens, and survival data were reviewed from the medical records of all patients. The Chi-square test was used to analyze the correlation between TRG and clinicopathological factors. Kaplan-Meier univariate analysis and Cox regression multivariate analysis were used to determine the independent risk factors affecting the prognosis of GC patients. Results: Among the 551 patients with advanced GC who accepted NACT treatment, 14 were determined to be in TRG 0, 98 in TRG 1, 257 in TRG 2, and 182 in TRG 3. Also, TRG was significantly correlated with the cT stage (P=0.015), ypT stage (P<0.001), ypN stage (P<0.001), ypTNM stage (P<0.001), vascular tumor thrombus (P<0.001), Borrmann classification (P=0.042), and lymph node ratio (LNR) (P<0.001). Furthermore, patients who had a good pathological response to NACT had a better prognosis, with a 3-year overall survival (OS) of 70.9% versus 48.8% in patients who had a poor pathological response. We also found that TRG (P=0.042, HR =1.65) was an independent prognostic factor affecting the OS of GC patients. Conclusions: TRG plays a significant role in the prognostic value in neoadjuvant chemotherapy for gastric adenocarcinoma. Patients with higher cT stage, higher levels of pre-CA199 and pre-CA125 may have worse pathological response.
WOS关键词PERIOPERATIVE CHEMOTHERAPY ; CANCER ; SURVIVAL ; SURGERY
资助项目Diagnosis and Therapy Center of Upper Gastrointestinal Tumor[JBZX-202006] ; Natural Science Foundation of Zhejiang Province[LY18H290006] ; Key research and development project of Zhejiang Science and Technology Department[2019C03049] ; National Natural Science Foundation of China[81973634] ; National Natural Science Foundation of China[82074245] ; Program of Zhejiang Provincial TCM Sci-tech Plan[2019ZZ010] ; Program of Zhejiang Provincial TCM Sci-tech Plan[2021ZA020]
WOS研究方向Oncology ; Gastroenterology & Hepatology
语种英语
出版者AME PUBL CO
WOS记录号WOS:000815705200001
资助机构Diagnosis and Therapy Center of Upper Gastrointestinal Tumor ; Natural Science Foundation of Zhejiang Province ; Key research and development project of Zhejiang Science and Technology Department ; National Natural Science Foundation of China ; Program of Zhejiang Provincial TCM Sci-tech Plan
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/129596]  
专题中国科学院合肥物质科学研究院
通讯作者Xu, Zhiyuan; Cheng, Xiangdong
作者单位1.Katholieke Univ Leuven, Div Anim & Human Hlth Engn, Dept Biosyst, Leuven, Belgium
2.Zhejiang Chinese Med Univ, Clin Med Coll 1, Hangzhou, Peoples R China
3.Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Dept Gastr Surg,Canc Hosp,Univ Chinese Acad Sci, Hangzhou, Peoples R China
4.Diag & Therapy Ctr Upper Gastrointestinal Tumor Z, Hangzhou, Peoples R China
5.Int Cooperat Base Canc Mol Diag & Intelligent Scr, Hangzhou, Peoples R China
6.Leuven Hlth Technol Ctr China Ctr, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yi,Xu, Handong,Hu, Can,et al. Prognostic value and clinicopathological correlation of the tumor regression grade in neoadjuvant chemotherapy for gastric adenocarcinoma: a retrospective cohort study[J]. JOURNAL OF GASTROINTESTINAL ONCOLOGY,2022.
APA Wang, Yi.,Xu, Handong.,Hu, Can.,Yu, Pengcheng.,Bao, Zhehan.,...&Cheng, Xiangdong.(2022).Prognostic value and clinicopathological correlation of the tumor regression grade in neoadjuvant chemotherapy for gastric adenocarcinoma: a retrospective cohort study.JOURNAL OF GASTROINTESTINAL ONCOLOGY.
MLA Wang, Yi,et al."Prognostic value and clinicopathological correlation of the tumor regression grade in neoadjuvant chemotherapy for gastric adenocarcinoma: a retrospective cohort study".JOURNAL OF GASTROINTESTINAL ONCOLOGY (2022).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。