Impact of gadolinium on mechanical properties, corrosion resistance, and biocompatibility of Zn-1Mg-xGd alloys for biodegradable bone-implant applications
文献类型：期刊论文
| 作者 | Tong, Xian2,3,4; Zhu, Li3; Wang, Kun4 ; Shi, Zimu1; Huang, Shengbin3; Li, Yuncang5; Ma, Jianfeng3; Wen, Cuie5; Lin, Jixing3
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| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2022-04-01 |
| 卷号 | 142 |
| ISSN号 | 1742-7061 |
| 关键词 | Zn-Mg-Gd alloy Mechanical properties Corrosion behavior Anticoagulation Biocompatibility |
| DOI | 10.1016/j.actbio.2022.02.015 |
| 通讯作者 | Wang, Kun(wangkunccc@zjitc.edu.cn) ; Ma, Jianfeng(dentistmacn@aliyun.com) ; Wen, Cuie(cuie.wen@rmit.edu.au) ; Lin, Jixing(jixing.lin@wmu.edu.cn) |
| 英文摘要 | Zinc (Zn) and its alloys are currently regarded as one of the promising families of biodegradable metals for implant applications owing to their suitable biodegradability and biofunctionality. However, the inadequate mechanical properties of as-cast (AC) pure Zn restricted the practical clinical bone-implant applications due to its coarse grain size and hexagon close-packed crystal structure. Here, the impact of gadolinium (Gd) on the mechanical properties, corrosion resistance, hemolysis percentage, anticoagulant activity, and cytotoxicity of AC and hot-rolled (HR) Zn-1Mg-xGd (x = 0.1, 0.2, and 0.3) (wt.%) alloys were investigated for biodegradable bone-implant applications. Tensile testing showed that the HR Zn-1Mg0.3Gd alloy exhibited the highest tensile strength of 288.1 MPa, tensile yield strength of 250.9 MPa, and elongation of 13.2%. Electrochemical corrosion and immersion tests revealed that the corrosion rates of both AC and HR specimens increased with increasing Gd content in Hanks' solution, and the HR Zn-1MgxGd specimens exhibited higher corrosion rates compared to their AC counterparts. The HR Zn-1Mg-xGd specimens showed an increasing hemolysis percentages and decreasing activated partial thromboplastin time (APTT) values with increasing Gd addition. The alloy extracts of HR samples at = 25% concentration exhibited no cytotoxicity toward MG-63 cells, and the HR Zn-1Mg-0.3Gd alloy displayed the highest cell viability among all three alloy extracts at 12.5% concentration. Overall, the HR Zn-1Mg-0.3Gd can be considered a promising biodegradable implant material for bone-implant materials owing to its high mechanical strength and ductility, suitable degradation rate, and satisfying biocompatibility. Statement of significance In this work, Zn-1Mg-xGd (x = 0.1, 0.2, and 0.3 wt.%) alloys were developed by alloying with gadolinium (Gd) and hot-rolling, and their mechanical properties, corrosion behavior, hemolysis percentage, anticoagulant activity, and cytotoxicity were investigated for biodegradable implant application. Our findings demonstrated that the hot-rolled Zn-1Mg-0.3Gd alloy exhibit the highest ultimate tensile strength of 288.1 MPa, yield strength of 250.9 MPa, and elongation of 13.2%. Hot-rolled Zn-1Mg-xGd alloys show slowly increasing hemolysis percentages and decreasing activated partial thromboplastin time (APTT) values with increasing Gd addition. Extracts of hot-rolled Zn-1Mg-xGd alloys at a concentration of = 25% show no cytotoxicity towards MG-63 cells, and Zn-1Mg-0.3Gd exhibit good cytocompatibility among all three alloys at a concentration of 12.5%. (C) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | ZN-ZR ALLOY ; GD-ZN ; RARE-EARTH ; MG ALLOY ; MICROSTRUCTURE ; MAGNESIUM ; RECRYSTALLIZATION ; BEHAVIOR ; DY ; CYTOTOXICITY |
| 资助项目 | Hunan Provincial Innovation Foundation for Postgraduate[XDCX2021B130] ; Wenzhou Science and Technology Bureau[2018ZY012] ; Wenzhou Science and Technology Bureau[ZG2020020] ; Australian Research Council (ARC)[DP210101862] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000873453600001 |
| 资助机构 | Hunan Provincial Innovation Foundation for Postgraduate ; Wenzhou Science and Technology Bureau ; Australian Research Council (ARC) |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/129823]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Kun; Ma, Jianfeng; Wen, Cuie; Lin, Jixing |
| 作者单位 | 1.Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Peoples R China 2.Xiangtan Univ, Sch Mat Sci & Engn, Xiangtan 411105, Peoples R China 3.Wenzhou Med Univ, Sch & Hosp Stomatol, Inst Stomatol, Wenzhou 325027, Peoples R China 4.Zhejiang Ind & Trade Vocat Coll, Coll Optoelect Mfg, Wenzhou 325003, Peoples R China 5.RMIT Univ, Sch Engn, Melbourne, Vic 3001, Australia |
| 推荐引用方式 GB/T 7714 | Tong, Xian,Zhu, Li,Wang, Kun,et al. Impact of gadolinium on mechanical properties, corrosion resistance, and biocompatibility of Zn-1Mg-xGd alloys for biodegradable bone-implant applications[J]. ACTA BIOMATERIALIA,2022,142. |
| APA | Tong, Xian.,Zhu, Li.,Wang, Kun.,Shi, Zimu.,Huang, Shengbin.,...&Lin, Jixing.(2022).Impact of gadolinium on mechanical properties, corrosion resistance, and biocompatibility of Zn-1Mg-xGd alloys for biodegradable bone-implant applications.ACTA BIOMATERIALIA,142. |
| MLA | Tong, Xian,et al."Impact of gadolinium on mechanical properties, corrosion resistance, and biocompatibility of Zn-1Mg-xGd alloys for biodegradable bone-implant applications".ACTA BIOMATERIALIA 142(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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