A model of radiation-induced temporomandibular joint damage in mice
文献类型：期刊论文
| 作者 | Zhang, Peng2; Yao, Lejing2; Shan, Guoping2; Chen, Yuanyuan1,3 |
| 刊名 | INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
 |
| 出版日期 | 2022-11-02 |
| 卷号 | 98 |
| ISSN号 | 0955-3002 |
| 关键词 | C57BL 6 C3H mice temporomandibular joint SARRP precise irradiation radioactive injury fibrosis osteocytic necrosis |
| DOI | 10.1080/09553002.2022.2069298 |
| 通讯作者 | Chen, Yuanyuan(chenyy2@sysucc.org.cn) |
| 英文摘要 | Purpose A small animal radiation research platform (SARRP) equipped with a miniature beam system, an image-guided positioning system, and a dose planning system was used to develop and evaluate a mouse model of radiation-induced temporomandibular damage. Methods Left jaw disks of adult male C57BL/6 mice and C3H mice were targeted using the SARRP for image-guided irradiation. The total radiation dose was 75 Gy. Experiment 1 (Scoping study): Mice in the C57BL/6 mouse test and control groups were sacrificed at 1, 3, 6, 9, 12, 15, and 18 weeks after irradiation, whereas mice in the C3H test and control groups were sacrificed at 1, 3, 6, 9, and 12 weeks after irradiation. Experiment 2 (Full -scale validation study): Mice in the C57BL/6 mouse test and control groups were sacrificed at 1, 3 and 6 weeks after irradiation. Histopathological analysis of the temporomandibular skeletal muscle in each group was performed using hematoxylin and eosin (H&E) and Masson staining; the temporal mandibular bone was examined through H&E staining. Results SARRP delivered the rated dose to the temporomandibular joints of C57BL/6 and C3H mice. C3H and C57BL/6 mice in the test group showed different degrees of osteocytic necrosis and osteoporosis at different time points. H&E staining of skeletal muscle tissue showed slight fibrosis in the C57BL/6 test at 3 and 6 weeks time point. Conclusion We established a model of radiation-induced damage in the temporomandibular joint of C57BL/6 mice and demonstrated that the observed physiological and histological changes correspond to radiation damage observed in humans. Furthermore, the SARRP can deliver precise radiation doses. |
| WOS关键词 | NASOPHARYNGEAL CARCINOMA ; CRANIAL IRRADIATION ; TOMOGRAPHY SYSTEM ; RAT MODEL ; RADIOTHERAPY ; FIBROSIS ; COMPLICATIONS ; CALIBRATION ; HEAD |
| 资助项目 | Zhejiang Medical and Health Science and Technology Project [New Technology Product RD Project][2019PY002] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS LTD |
| WOS记录号 | WOS:000790650300001 |
| 资助机构 | Zhejiang Medical and Health Science and Technology Project [New Technology Product RD Project] |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/129931]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Chen, Yuanyuan |
| 作者单位 | 1.Chinese Acad Sci, Dept Radiol Oncol, Zhejiang Key Lab Radiat Oncol,Inst Basic Med & Ca, Canc Hosp,Univ Chinese Acad Sci,Zhejiang Canc Hos, Hangzhou, Peoples R China 2.Chinese Acad Sci, Dept Radiol Phys, Zhejiang Key Lab Radiat Oncol,Inst Basic Med & Ca, Canc Hosp,Univ Chinese Acad Sci,Zhejiang Canc Hos, Hangzhou, Peoples R China 3.Sun Yat Sen Univ, Dept Radiat Oncol, Canc Ctr, Guangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Peng,Yao, Lejing,Shan, Guoping,et al. A model of radiation-induced temporomandibular joint damage in mice[J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY,2022,98. |
| APA | Zhang, Peng,Yao, Lejing,Shan, Guoping,&Chen, Yuanyuan.(2022).A model of radiation-induced temporomandibular joint damage in mice.INTERNATIONAL JOURNAL OF RADIATION BIOLOGY,98. |
| MLA | Zhang, Peng,et al."A model of radiation-induced temporomandibular joint damage in mice".INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 98(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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