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A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus

文献类型：期刊论文

作者Yuan, Bingqian2,3,4,5; Lu, Xiaoyu2,3,4,5; Yang, Min3,4,6; He, Qiyi7; Cha, Zhuocen1,8; Fang, Yaqun3; Yang, Yan4,9; Xu, Lei9; Yan, Jingting9; Lai, Ren3,4
刊名FRONTIERS IN MICROBIOLOGY
出版日期2022-10-10
卷号13
关键词Staphylococcus aureus cathelicidin antimicrobial peptides GW18 drug-resistant
DOI10.3389/fmicb.2022.1029366
通讯作者Wang, Aili(allie612@gmlab.ac.cn) ; Yu, Xiaodong(yxd@cqnu.edu.cn) ; Duan, Zilei(duanzilei@mail.kiz.ac.cn)
英文摘要Staphylococcus aureus (S. aureus) is a Gram-positive pathogenic bacterium, which persistently colonizes the anterior nares of approximately 20-30% of the healthy adult population, and up to 60% is intermittently colonized. With the misuse and overuse of antibiotics, large-scale drug-resistant bacteria, including methicillin-resistant S. aureus (MRSA), have been appeared. MRSA is among the most prevalent pathogens causing community-associated infections. Once out of control, the number of deaths caused by antimicrobial resistance may exceed 10 million annually by 2050. Antimicrobial peptides (AMPs) are regarded as the best solution, for they are not easy to develop drug resistance. Based on our previous research, here we designed a new antimicrobial peptide named GW18, which showed excellent antimicrobial activity against S. aureus, even MRSA, with the hemolysis less than 5%, no cytotoxicity, and no acute toxicity. Notably, administration of GW18 significantly decreased S. aureus infection in mouse model. These findings identify GW18 as the ideal candidate against S. aureus infection.
WOS关键词PROTEASE STABILITY ; CATHELICIDIN ; LL-37 ; COMPLEX ; SEPSIS ; DNA
资助项目National Natural Science Foundation of China[31930015] ; National Natural Science Foundation of China[81770464] ; National Natural Science Foundation of China[U2002219] ; National Natural Science Foundation of China[32002311] ; Chinese Academy of Sciences[SAJC202103] ; Chinese Academy of Sciences[XDB31000000] ; Chinese Academy of Sciences[KFJ-BRP-008] ; Yunnan Provincial Science and Technology Department[202002AA100007] ; Yunnan Provincial Science and Technology Department[2019FB127] ; Yunnan Provincial Science and Technology Department[202001AT070128] ; Bureau of Industry and Information Technology of Kunming[2120784001315] ; Bureau of Industry and Information Technology of Kunming[2120784001310] ; Kunming Science and Technology Bureau[2023SCP001] ; Chongqing Municipal Education Commission[HZ2021020]
WOS研究方向Microbiology
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000876195100001
资助机构National Natural Science Foundation of China ; Chinese Academy of Sciences ; Yunnan Provincial Science and Technology Department ; Bureau of Industry and Information Technology of Kunming ; Kunming Science and Technology Bureau ; Chongqing Municipal Education Commission
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/130051]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Aili; Yu, Xiaodong; Duan, Zilei
作者单位1.Yunnan Canc Hosp, Kunming, Yunnan, Peoples R China
2.Tianjin Univ, Sch Life Sci, Tianjin, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool,Sino African Joint Res Ctr, Natl Resource Ctr Nonhuman Primates,Key Lab Bioact, Kunming Primate Res Ctr,Key Lab Anim Models & Huma, Kunming, Peoples R China
4.Kunming Inst Zool, Engn Lab Peptides, Kunming, Peoples R China
5.Univ Chinese Acad Sci, Chinese Acad Sci, Canc Hosp, Inst Basic Med & Canc IBMC, Hangzhou, Zhejiang, Peoples R China
6.Univ Chinese Acad Sci, Kunming Coll Life Sci, Beijing, Peoples R China
7.Chongqing Normal Univ, Coll Life Sci, Chongqing, Peoples R China
8.Kunming Med Univ, Affiliated Hosp 3, Dept Breast Surg, Kunming, Yunnan, Peoples R China
9.Yunnan Prov Acad Sci & Technol, Kunming, Peoples R China
10.Southern Marine Sci & Engn Guangdong Lab, Ctr Evolut & Conservat Biol, Guangzhou, Peoples R China
推荐引用方式
GB/T 7714		 Yuan, Bingqian,Lu, Xiaoyu,Yang, Min,et al. A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus[J]. FRONTIERS IN MICROBIOLOGY,2022,13.
APA Yuan, Bingqian.,Lu, Xiaoyu.,Yang, Min.,He, Qiyi.,Cha, Zhuocen.,...&Duan, Zilei.(2022).A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus.FRONTIERS IN MICROBIOLOGY,13.
MLA Yuan, Bingqian,et al."A designed antimicrobial peptide with potential ability against methicillin resistant Staphylococcus aureus".FRONTIERS IN MICROBIOLOGY 13(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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