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The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma

文献类型：期刊论文

作者Wang, Xiaojing1,4; Zhao, Yue2,3; Strohmer, Dorothee Franziska3; Yang, Wenjin1; Xia, Zhijia3; Yu, Cong1
刊名FRONTIERS IN GENETICS
出版日期2022-08-30
卷号13
关键词fatty acid metabolism MicroRNAs head and neck squamous cell carcinoma prognostic risk score
DOI10.3389/fgene.2022.983672
通讯作者Xia, Zhijia(Zhijia.Xia@med.uni-muenchen.de) ; Yu, Cong(yucong18270916759@163.com)
英文摘要Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer in humans globally. In addition to smoking and drinking, genetic and epigenetic changes also play a big role in how HNSCC starts and grows. MicroRNAs are short, non-coding RNAs that control cell differentiation and apoptosis by interfering with gene expression. In addition, microRNAs in HNSCC have been shown to affect the clinical behaviors of HNSCC in amazing ways. Moreover, metabolic reprogramming is a key part of cancer and is needed for cancer to turn into a tumor and grow. But it is still not clear what effect microRNAs related to fatty acid metabolism have on the prognosis of HNSCC patients. We downloaded the data of HNSCC patients from the TCGA database and obtained the genes associated with fatty acid metabolism according to the GSEA database. Then, the microRNAs associated with fatty acid metabolism genes were matched. Finally, fatty acid metabolism gene associated microRNAs for calculating risk scores and then building multifactorial Cox regression models in patients with HNSCC. Heatmap analysis showed that microRNAs involved in fatty acid metabolism were significantly different in HNSCC patients than in healthy controls. A total of 27 microRNAs associated with fatty acid metabolism were screened by univariate Cox analysis (p < 0.05). Using lasso regression, 18 microRNAs substantially linked with the prognosis of HNSCC patients were identified and included in risk scores. The ROC curves demonstrate that risk scores derived from microRNAs involved in fatty acid metabolism can accurately predict the prognosis of HNSCC patients at 1, 3, and 5 years. Moreover, we discovered that 11 microRNAs included in the risk score properly distinguished the prognosis of HNSCC patients. This paper indicated that microRNAs involved with fatty acid metabolism are strongly linked to the prognosis of HNSCC patients. It also indicated that reprogramming of fatty acid metabolism in tumor tissues may play an important role in HNSCC cancer.
WOS关键词TUMOR MICROENVIRONMENT ; INHIBITION
资助项目Pudong Health Commission of Shanghai ; [PW2020A-14]
WOS研究方向Genetics & Heredity
语种英语
WOS记录号WOS:000883142400001
出版者FRONTIERS MEDIA SA
资助机构Pudong Health Commission of Shanghai
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/130110]  
专题中国科学院合肥物质科学研究院
通讯作者Xia, Zhijia; Yu, Cong
作者单位1.Shanghai Pudong New Area Peoples Hosp, Dept Neurosurg, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Breast Surg, Canc Hosp, Hangzhou, Peoples R China
3.Ludwig Maximilians Univ Munchen, Dept Gen Visceral & Transplant Surg, Munich, Germany
4.Anhui Med Univ, Dept Neurol, Affiliated Hosp 1, Hefei, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xiaojing,Zhao, Yue,Strohmer, Dorothee Franziska,et al. The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma[J]. FRONTIERS IN GENETICS,2022,13.
APA Wang, Xiaojing,Zhao, Yue,Strohmer, Dorothee Franziska,Yang, Wenjin,Xia, Zhijia,&Yu, Cong.(2022).The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma.FRONTIERS IN GENETICS,13.
MLA Wang, Xiaojing,et al."The prognostic value of MicroRNAs associated with fatty acid metabolism in head and neck squamous cell carcinoma".FRONTIERS IN GENETICS 13(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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