Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer
文献类型：期刊论文
| 作者 | Xu, Yuan-rui1,2; Wang, An-long2; Li, Ya-qing2 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2022-10-21 |
| 卷号 | 12 |
| 关键词 | chronic obstructive pulmonary disease lung cancer non-small cell lung cancer hypoxia-inducible factor 1-alpha hypoxia-inducible factor 1 |
| ISSN号 | 2234-943X |
| DOI | 10.3389/fonc.2022.984525 |
| 通讯作者 | Li, Ya-qing(lidoctor03@126.com) |
| 英文摘要 | Patients with chronic obstructive pulmonary disease (COPD), irrespective of their smoking history, are more likely to develop lung cancer than the general population. This is mainly because COPD is characterized by chronic persistent inflammation and hypoxia, which are the risk factors for lung cancer. However, the mechanisms underlying this observation are still unknown. Hypoxia-inducible factor 1-alpha (HIF-1 alpha) plays an important role in the crosstalk that exists between inflammation and hypoxia. Furthermore, HIF-1 alpha is the main regulator of somatic adaptation to hypoxia and is highly expressed in hypoxic environments. In this review, we discuss the molecular aspects of the crosstalk between hypoxia and inflammation, showing that HIF-1 alpha is an important signaling pathway that drives COPD progression to lung cancer. Here, we also provide an overview of HIF-1 alpha and its principal regulatory mechanisms, briefly describe HIF-1 alpha-targeted therapy in lung cancer, and summarize substances that may be used to target HIF-1 alpha at the level of COPD-induced inflammation. |
| WOS关键词 | TUMOR-GROWTH ; KAPPA-B ; TRANSCRIPTIONAL ACTIVITY ; DIRECT PHOSPHORYLATION ; SIRTUIN 1 ; HIF-1-ALPHA ; EXPRESSION ; COPD ; ANGIOGENESIS ; SUPPRESSES |
| 资助项目 | National Natural Science Foundation of China ; Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents ; [81870028] ; [81470241] ; [A-2017-CXCR02] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000879238600001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130134]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Li, Ya-qing |
| 作者单位 | 1.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Zhejiang, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yuan-rui,Wang, An-long,Li, Ya-qing. Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer[J]. FRONTIERS IN ONCOLOGY,2022,12. |
| APA | Xu, Yuan-rui,Wang, An-long,&Li, Ya-qing.(2022).Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer.FRONTIERS IN ONCOLOGY,12. |
| MLA | Xu, Yuan-rui,et al."Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer".FRONTIERS IN ONCOLOGY 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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