Pulmonary Epithelial-Myoepithelial Carcinoma
文献类型：期刊论文
| 作者 | Chen, Lingru1,2,3,4; Fan, Ying1,2,3,4; Lu, Hongyang1,2,3,4 |
| 刊名 | JOURNAL OF ONCOLOGY
 |
| 出版日期 | 2022-10-11 |
| 卷号 | 2022 |
| ISSN号 | 1687-8450 |
| DOI | 10.1155/2022/4559550 |
| 通讯作者 | Lu, Hongyang(luhy@zjcc.org.cn) |
| 英文摘要 | Pulmonary epithelial-myoepithelial carcinoma (P-EMC) is an exceptionally rare subtype of salivary gland lung tumor originating from tracheobronchial glands. P-EMC is a biphasic tumor consisting of an inner layer of epithelial cells and an outer layer of spindle-shaped, clear-cell-like myoepithelial cells. Bronchial obstruction symptom is the main clinical characteristic for P-EMC. Because its clinical and imaging characteristics are highly similar to other types of non-small-cell lung cancer (NSCLC), it is easy to cause missed diagnosis and misdiagnosis. The diagnosis is mainly based on the pathology and immunohistochemistry with an inner layer of epithelial cells immunoreactive for cytokeratin and an outside layer of myoepithelial cells immunoreactive for S100 protein (S-100) and smooth muscle actin (SMA). Therefore, positive for cytokeratin, S-100 and SMA can assist in the diagnosis. Although in general, P-EMC is a low-grade malignant neoplasm, it may occasionally recur and metastasize. The optimal method for P-EMC treatment has not been established, and surgical resection is still the main clinical method. Radiotherapy and chemotherapy have been shown not sensitive for P-EMC treatment, whereas targeted therapy and immunotherapy have not evaluated in clinical practice. This review focuses on the pathological characteristics, molecular characteristics, diagnosis, treatment, and prognosis of P-EMC. |
| WOS关键词 | GLAND-TYPE TUMORS ; LUNG-CANCER ; SALIVARY ; ADENOMYOEPITHELIOMA ; METASTASES |
| 资助项目 | Zhejiang Province Medical Science and Technology Project ; [2020ZH001] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000876503600001 |
| 出版者 | HINDAWI LTD |
| 资助机构 | Zhejiang Province Medical Science and Technology Project |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130162]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Lu, Hongyang |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Zhejiang Key Lab Diag & Treatment Technol Thorac, Hangzhou 310022, Peoples R China 2.Wenzhou Med Univ, Wenzhou 325035, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Med Oncol, Hangzhou 310022, Peoples R China 4.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Lingru,Fan, Ying,Lu, Hongyang. Pulmonary Epithelial-Myoepithelial Carcinoma[J]. JOURNAL OF ONCOLOGY,2022,2022. |
| APA | Chen, Lingru,Fan, Ying,&Lu, Hongyang.(2022).Pulmonary Epithelial-Myoepithelial Carcinoma.JOURNAL OF ONCOLOGY,2022. |
| MLA | Chen, Lingru,et al."Pulmonary Epithelial-Myoepithelial Carcinoma".JOURNAL OF ONCOLOGY 2022(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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