Radiation dose escalation for locally advanced nasopharyngeal carcinoma patients with local and/or regional residual lesions after standard chemoradiotherapy: a non-randomized, observational study
文献类型：期刊论文
| 作者 | Jin, Ting1,2; Liu, Nan-Fang1,3; Jin, Qi-Feng1,2; Hua, Yong-Hong1,2; Chen, Xiao-Zhong1,2 |
| 刊名 | RADIATION ONCOLOGY
 |
| 出版日期 | 2022-11-07 |
| 卷号 | 17 |
| 关键词 | Nasopharyngeal carcinoma Boost Radiotherapy Residual lesion Chemotherapy |
| DOI | 10.1186/s13014-022-02147-7 |
| 通讯作者 | Chen, Xiao-Zhong(chenxiaozhong2016@163.com) |
| 英文摘要 | Background To assess the effectiveness and toxicity of radiation dose escalation for locally advanced nasopharyngeal carcinoma (LA-NPC) in patients with local and/or regional residual lesion(s) after standard treatment. Methods From November 2011 to November 2020, 259 LA-NPC patients who had local and/or regional residual lesion(s) after induction chemotherapy followed by concurrent chemoradiotherapy (IC + CCRT) from our hospital were included. The total dose of primary radiotherapy (RT) was 68.1-74.25 Gy (median, 70.4 Gy). The boost doses were 4.0-18.0 Gy (median, 9 Gy), 1.8-2.0 Gy/fraction. Results For all patients, the 5-year local relapse-free survival was 90.2%, regional relapse-free survival was 89.1%, locoregional relapse-free survival (LRRFS) was 79.5%, distant metastasis-free survival (DMFS) was 87.9%, failure-free survival (FFS) was 69.0%, and overall survival (OS) was 86.3%. LRRFS, DMFS, FFS, and OS in patients with age <= 65 versus > 65, plasma Epstein-Barr virus-deoxyribonucleic acid <= 500 versus > 500, T1-2 versus T3-4, N0-1 versus N2-3, and stage III versus stage IV showed no statistically significant differences. The interval between primary RT and boost was not a prognostic factor for LRRFS, DMFS, FFS, and OS. Males had a lower 3-year FFS rate than females (72.9% vs. 83.7%, P = 0.024). LA-NPCs with locally and regionally residual lesion(s) had the worst 3-year DMFS and OS rates compared with locally or regionally residual lesion(s) (77.7% vs. 98.8% vs. 87.4%, P = 0.014; 75.9% vs. 94.5% vs. 82.4%, P = 0.002). Conclusion Boost radiation was an option for LA-NPCs with locally and/or regionally residual lesions after receiving IC + CCRT. It warrants further prospective study. Trial registration: Retrospectively registered. |
| WOS关键词 | INTENSITY-MODULATED RADIOTHERAPY ; CONCURRENT CHEMORADIOTHERAPY ; INDUCTION CHEMOTHERAPY ; CISPLATIN ; THERAPY |
| 资助项目 | Zhejiang Province Medical and Health Science and Technology Project[2021KY596] ; Zhejiang Province Medical and Health Science and Technology Project[2022488934] ; Xiansheng Clinical Research Special Fund of China International Medical Exchange Foundation[Z-2014-06-2104] ; Shanghai Cancer Prevention and Anticancer Development Foundation 2020 Exploration Tumor Scientific Research Fund Project[6] |
| WOS研究方向 | Oncology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000879770100001 |
| 出版者 | BMC |
| 资助机构 | Zhejiang Province Medical and Health Science and Technology Project ; Xiansheng Clinical Research Special Fund of China International Medical Exchange Foundation ; Shanghai Cancer Prevention and Anticancer Development Foundation 2020 Exploration Tumor Scientific Research Fund Project |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130178]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Chen, Xiao-Zhong |
| 作者单位 | 1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Canc Hosp,Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China 2.Key Lab Head & Neck CancerTranslat Res Zhejiang P, Hangzhou 310022, Peoples R China 3.Zhejiang Canc Hosp, Dept Gynecol Radiat Oncol, Hangzhou 310022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Ting,Liu, Nan-Fang,Jin, Qi-Feng,et al. Radiation dose escalation for locally advanced nasopharyngeal carcinoma patients with local and/or regional residual lesions after standard chemoradiotherapy: a non-randomized, observational study[J]. RADIATION ONCOLOGY,2022,17. |
| APA | Jin, Ting,Liu, Nan-Fang,Jin, Qi-Feng,Hua, Yong-Hong,&Chen, Xiao-Zhong.(2022).Radiation dose escalation for locally advanced nasopharyngeal carcinoma patients with local and/or regional residual lesions after standard chemoradiotherapy: a non-randomized, observational study.RADIATION ONCOLOGY,17. |
| MLA | Jin, Ting,et al."Radiation dose escalation for locally advanced nasopharyngeal carcinoma patients with local and/or regional residual lesions after standard chemoradiotherapy: a non-randomized, observational study".RADIATION ONCOLOGY 17(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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