An Implantable Magnetic Vascular Scaffold for Circulating Tumor Cell Removal In Vivo
文献类型：期刊论文
| 作者 | Yin, Zhiwei2; Shi, Rui2; Xia, Xin2; Li, Ling2,3; Yang, Yanxia2; Li, Shengkai2; Xu, Jieqiong2; Xu, Yiting4; Cai, Xinqi2; Wang, Shen2 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2022-11-04 |
| ISSN号 | 0935-9648 |
| 关键词 | adhesion repertoires bioinspired ultrastructure circulating tumor cell removal magnetothermal response vascular-like integrated trapped devices |
| DOI | 10.1002/adma.202207870 |
| 通讯作者 | Chen, Zhuo(zhuochen@hnu.edu.cn) |
| 英文摘要 | An integrated trapped device (ITD) capable of removal of circulating tumor cells (CTCs) can assuage or even prevent metastasis. However, adhesion repertoires are ordinarily neglected in the design of ITDs, possibly leading to the omission of highly metastatic CTC and treatment failure. Here a vascular-like ITD with adhesive sites and wireless magnetothermal response to remove highly metastatic CTC in vivo is presented. Such a vascular-like ITD comprises circumferential well-aligned fibers and artificial adhesion repertoires and is optimized for magnetothermal integration. Continuous and repeated capture in a dynamic environment increases capture efficiency over time. Meanwhile, the heat generation of the ITD leads to the capture of CTC death owing to cell heat sensitivity. Furthermore, the constructed bioinspired ultrastructure of the ITD prevents vascular blockage and induces potential vascular regeneration. Overall, this work defines an extendable strategy for constructing adhesion repertoires against intravascular shear forces, provides a vascular-like ITD for reducing CTC counts, and is expected to alleviate the risk of cancer recurrence. |
| WOS关键词 | METASTASIS ; CAPTURE ; EXPRESSION ; SURVIVAL ; PHASE |
| 资助项目 | National Key Research and Development Program of China[2022YFC2403500] ; National Key Research and Development Program of China[2020YFA0210800] ; National Natural Science Foundation of China[22225401] ; Science and Technology Innovation Program of Hunan Province[2020RC4017] ; Youth Foundation of Hunan Province[2022JJ40147] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000878789500001 |
| 资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Science and Technology Innovation Program of Hunan Province ; Youth Foundation of Hunan Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130180]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Chen, Zhuo |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Inst Mol Med IMM, Renji Hosp, Sch Med, Shanghai 200240, Peoples R China 2.Hunan Univ, Mol Sci & Biomed Lab MBL, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Coll Biol,Aptamer Engn Ctr, Changsha 410082, Peoples R China 3.Chinese Acad Sci, Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp,Inst Basic Med & Canc IBMC, Hangzhou 310022, Peoples R China 4.Hunan Univ Sci & Technol, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China 5.Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defect Res & Prevent, Changsha 410008, Peoples R China 6.Hunan Childrens Hosp, Pediat Res Inst, Changsha 410007, Peoples R China 7.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Zhiwei,Shi, Rui,Xia, Xin,et al. An Implantable Magnetic Vascular Scaffold for Circulating Tumor Cell Removal In Vivo[J]. ADVANCED MATERIALS,2022. |
| APA | Yin, Zhiwei.,Shi, Rui.,Xia, Xin.,Li, Ling.,Yang, Yanxia.,...&Tan, Weihong.(2022).An Implantable Magnetic Vascular Scaffold for Circulating Tumor Cell Removal In Vivo.ADVANCED MATERIALS. |
| MLA | Yin, Zhiwei,et al."An Implantable Magnetic Vascular Scaffold for Circulating Tumor Cell Removal In Vivo".ADVANCED MATERIALS (2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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