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Transition-metal-doped hydrophilic ultrasmall iron oxide modulates MRI contrast performance for accurate diagnosis of orthotopic prostate cancer

文献类型：期刊论文

作者Xie, Wenteng1,2; Gan, Yuehao1,2; Zhang, Ya'nan3,4; Wang, Peng3,4; Zhang, Jia2; Qian, Junchao5; Zhang, Guilong3,4; Wu, Zhengyan2
刊名JOURNAL OF MATERIALS CHEMISTRY B
出版日期2022-11-30
卷号10
ISSN号2050-750X
DOI10.1039/d2tb01860h
通讯作者Qian, Junchao(qianjunchao@hmfl.ac.cn) ; Zhang, Guilong() ; Wu, Zhengyan(zywu@ipp.ac.cn)
英文摘要The FDA-approved iron oxide nanocrystals (IONs), as negative magnetic resonance imaging contrast agents (MRICAs), face challenges because of their low relaxation rate and coherent ferromagnetism. Although research has found that metal doping is an efficient approach to improve the magnetic property and MRI contrast performance of IONs, their systemic mechanism has not been fully explained. Herein, we fabricated a series of transition-metal-doped IONs and systemically explored their sizes, structures, and variation in magnetic properties, revealing the oxygen vacancy-mediated MRI contrast enhancement mechanism of transition-metal-doped IONs. Based on these, we found that Zn-doped IONs possess optimal T-2 MRI contrast performance and further investigated their potential to diagnose in vivo orthotopic tumor as a T-2 contrast agent. The results indicate that the use of Zn-doped IONs significantly enhances T-2-weighted MRI signal intensity of orthotopic prostate tumor with low toxicity, which is beneficial for the accurate diagnosis of orthotopic tumor. Collectively, this work clearly illustrates the mechanism of contrast enhancement of transition-metal-doped IONs and provides a novel paradigm for developing a highly efficient T-2 contrast agent.
WOS关键词MAGNETITE NANOPARTICLES ; OXYGEN VACANCIES
资助项目National Natural Science Foundation of China[22007006] ; National Natural Science Foundation of China[31771284] ; National Natural Science Foundation of China[81902710] ; National Natural Science Foundation of China[82072055] ; Taishan Scholars Construction Engineering[tsqn20161047] ; Taishan Scholars Construction Engineering[tsqn201909144] ; Special Project of Central Government for Local Science and Technology Development of Shandong Province[YDZX20203700001291] ; Supporting Projects for Distinguished Young Scholar of Anhui Colleges[gxyqZD2019018] ; Supporting Projects for Distinguished Young Scholar of Anhui Colleges[2021-108] ; University Synergy Innovation Program of Anhui Province[GXXT-2021-059] ; Plan for Anhui Major Provincial Science and Technology Project[202203a06020001]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000883756100001
出版者ROYAL SOC CHEMISTRY
资助机构National Natural Science Foundation of China ; Taishan Scholars Construction Engineering ; Special Project of Central Government for Local Science and Technology Development of Shandong Province ; Supporting Projects for Distinguished Young Scholar of Anhui Colleges ; University Synergy Innovation Program of Anhui Province ; Plan for Anhui Major Provincial Science and Technology Project
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/130283]  
专题中国科学院合肥物质科学研究院
通讯作者Qian, Junchao; Zhang, Guilong; Wu, Zhengyan
作者单位1.Univ Sci & Technol China, Hefei 230026, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Shandong Technol Innovat Ctr Mol Targeting & Intel, Yantai 264003, Peoples R China
4.Binzhou Med Univ, Inst Biomed Imaging Probe, Yantai 264003, Peoples R China
5.Chinese Acad Sci, Hefei Canc Hosp, Hefei Inst Phys Sci, Inst Hlth & Med Technol,Anhui Prov Key Lab Med Phy, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Xie, Wenteng,Gan, Yuehao,Zhang, Ya'nan,et al. Transition-metal-doped hydrophilic ultrasmall iron oxide modulates MRI contrast performance for accurate diagnosis of orthotopic prostate cancer[J]. JOURNAL OF MATERIALS CHEMISTRY B,2022,10.
APA Xie, Wenteng.,Gan, Yuehao.,Zhang, Ya'nan.,Wang, Peng.,Zhang, Jia.,...&Wu, Zhengyan.(2022).Transition-metal-doped hydrophilic ultrasmall iron oxide modulates MRI contrast performance for accurate diagnosis of orthotopic prostate cancer.JOURNAL OF MATERIALS CHEMISTRY B,10.
MLA Xie, Wenteng,et al."Transition-metal-doped hydrophilic ultrasmall iron oxide modulates MRI contrast performance for accurate diagnosis of orthotopic prostate cancer".JOURNAL OF MATERIALS CHEMISTRY B 10(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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