Parotid Gland Stem Cell Preservation during Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma: Dosimetric Analysis and Feasibility
文献类型：期刊论文
| 作者 | Zheng, Lirong2; Mei, Qiaoli3; Gao, Yuxiang2; Du, Fenglei4; Xiao, Lin5; Wu, Gangfeng1 |
| 刊名 | JOURNAL OF ONCOLOGY
 |
| 出版日期 | 2022-07-12 |
| 卷号 | 2022 |
| ISSN号 | 1687-8450 |
| DOI | 10.1155/2022/4922409 |
| 通讯作者 | Wu, Gangfeng(wugangfeng1981@163.com) |
| 英文摘要 | Objective. Parotid gland (PG) is a radiosensitive organ, and xerostomia (XS) is a key factor affecting patients' life quality after conventional radiotherapy for head and neck tumors. In this study, dosimetry analysis was performed on PG stem cell preservation in intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC). Methods. All clinical data of 80 NPC patients diagnosed pathologically in the Radiotherapy Department of Taizhou Hospital of Zhejiang Province Affiliated with Wenzhou Medical University from August 2017 to September 2019 were retrospectively analyzed. Patients were assigned to a regular group and a restricted group according to different IMRT plans, in which a dose limitation for the parotid duct was added in the restricted group in addition to the conventional plan used in the regular group to minimize the parotid duct radiation dose. The differences in planning target volume (PTV) dose distribution, organ at risk (OAR) dose, and dose to the PG and its ducts were compared between the two groups. Results. Significantly higher mean irradiation doses of the brainstem, mandible, and oral cavity were determined in the restricted group compared with the regular group (P > 0.05), but there was no significant difference in the mean dose of other OARs irradiated (P > 0.05). As compared to the irradiation of bilateral PGs, no statistical differences were found in the mean irradiation dose and V-30 between regular and restricted groups (P > 0.05), but lower V-20 and higher V-45 were determined in the restricted group (P < 0.05). The mean irradiation dose, V-15, V-20, and V-26 of bilateral parotid ducts were lower in the restricted group as compared to the regular group (P < 0.05). Conclusion. IMRT for NPC can effectively reduce the mean irradiation dose and play a PG stem cell preservation role by giving specific dose limitation conditions to the parotid duct area without affecting PTV dose distribution and OAR irradiation dose, which has certain feasibility. |
| WOS关键词 | RADIATION-THERAPY ; SUBMANDIBULAR-GLANDS ; NECK TUMORS ; SALIVARY ; HEAD ; CANCER ; MECHANISM ; EDITION ; INJURY ; MODEL |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | HINDAWI LTD |
| WOS记录号 | WOS:000885755400002 |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130293]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wu, Gangfeng |
| 作者单位 | 1.Tai Zhou Second Peoples Hosp, Dept ENT, Taizhou 317000, Zhejiang, Peoples R China 2.Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Dept ENT, Taizhou 317000, Zhejiang, Peoples R China 3.Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Dept Pharm, Taizhou 317000, Zhejiang, Peoples R China 4.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Radiotherapy, Canc Hosp, Hangzhou 310000, Zhejiang, Peoples R China 5.Enze Hosp, Dept Otolaryngol, Taizhou Enze Med Ctr Grp, Taizhou 317000, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Lirong,Mei, Qiaoli,Gao, Yuxiang,et al. Parotid Gland Stem Cell Preservation during Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma: Dosimetric Analysis and Feasibility[J]. JOURNAL OF ONCOLOGY,2022,2022. |
| APA | Zheng, Lirong,Mei, Qiaoli,Gao, Yuxiang,Du, Fenglei,Xiao, Lin,&Wu, Gangfeng.(2022).Parotid Gland Stem Cell Preservation during Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma: Dosimetric Analysis and Feasibility.JOURNAL OF ONCOLOGY,2022. |
| MLA | Zheng, Lirong,et al."Parotid Gland Stem Cell Preservation during Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma: Dosimetric Analysis and Feasibility".JOURNAL OF ONCOLOGY 2022(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。