Xin-Ji-Er-Kang Alleviates Isoproterenol-Induced Myocardial Hypertrophy in Mice through the Nrf2/HO-1 Signaling Pathway
文献类型：期刊论文
| 作者 | Yu, Ting-Ting5; Sun, Li-Jun2; Chen, Chen2; Wang, Zi-Jian3; Liu, Xue-Sheng4; Zhu, Feng-Qin1; Gao, Shan2 |
| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2022-08-22 |
| 卷号 | 2022 |
| ISSN号 | 1741-427X |
| DOI | 10.1155/2022/7229080 |
| 通讯作者 | Gao, Shan(gaoshan@ahmu.edu.cn) |
| 英文摘要 | Xin-Ji-Er-Kang (XJEK) inhibited cardiovascular remodeling in hypertensive mice in our previous studies. We hypothesized that XJEK may prevent isoproterenol (ISO)-induced myocardial hypertrophy (MH) in mice by ameliorating oxidative stress (OS) through a mechanism that may be related to the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1(HO-1) pathways. Forty SPF male Kunming mice were randomized into 5 groups (n = 8 mice per group): control group, MH group, MH+ diTerent doses of XJEK (7.5 g/kg/day and 10 g/kg/day), and MH+ metoprolol (60 mg/kg/day). On the eighth day after drug treatment, electrocardiogram (ECG) and echocardiography were performed, the mice were sacrioced, and blood and heart tissues were collected for further analysis. XJEK administration markedly ameliorated cardiovascular remodeling (CR), as manifested by a decreased HW/BW ratio and CSA and less collagen deposition after MH. XJEK administration also improved MH, as evidenced by decreased atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and.-myosin heavy chain (beta-MHC) levels. XJEK also suppressed the decreased superoxide dismutase (SOD) and catalase (CAT) activities and increased malondialdehyde (MDA) levels in serum of mice with MH. XJEK-induced oxidative stress may be related to potentiating Nrf2 nuclear translocation and HO-1 expression compared with the MH groups. XJEK ameliorates MH by activating the Nrf2/HO-1 signaling pathway, suggesting that XJEK is a potential treatment for MH. |
| WOS关键词 | TRANSCRIPTION FACTOR NRF2 ; OXIDATIVE STRESS ; CARDIAC-HYPERTROPHY ; DISEASES |
| 资助项目 | National Natural Science Foundation of China[818731226] ; Special Professor of Wanjiang Scholars (2019) ; Anhui Provincial Institute of Translational Medicine Research Fund[2021zhyx-C20] ; Basic and clinical cooperation research promotion plan from Anhui Medical University[2021xkjT020] |
| WOS研究方向 | Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000884006500012 |
| 出版者 | HINDAWI LTD |
| 资助机构 | National Natural Science Foundation of China ; Special Professor of Wanjiang Scholars (2019) ; Anhui Provincial Institute of Translational Medicine Research Fund ; Basic and clinical cooperation research promotion plan from Anhui Medical University |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130297]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Gao, Shan |
| 作者单位 | 1.Chinese Acad Sci, Canc Hosp, Hefei 230032, Anhui, Peoples R China 2.Anhui Med Univ, Dept Pharmacol, Basic Med Coll, Hefei 230032, Anhui, Peoples R China 3.Anhui Med Univ, Med Clin, Sch Med, Hefei 230032, Anhui, Peoples R China 4.Anhui Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Hefei 230032, Anhui, Peoples R China 5.Wannan Med Coll, Dept Funct Expt Training Ctr, Basic Med Coll, Wuhu 241002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Ting-Ting,Sun, Li-Jun,Chen, Chen,et al. Xin-Ji-Er-Kang Alleviates Isoproterenol-Induced Myocardial Hypertrophy in Mice through the Nrf2/HO-1 Signaling Pathway[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2022,2022. |
| APA | Yu, Ting-Ting.,Sun, Li-Jun.,Chen, Chen.,Wang, Zi-Jian.,Liu, Xue-Sheng.,...&Gao, Shan.(2022).Xin-Ji-Er-Kang Alleviates Isoproterenol-Induced Myocardial Hypertrophy in Mice through the Nrf2/HO-1 Signaling Pathway.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2022. |
| MLA | Yu, Ting-Ting,et al."Xin-Ji-Er-Kang Alleviates Isoproterenol-Induced Myocardial Hypertrophy in Mice through the Nrf2/HO-1 Signaling Pathway".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2022(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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