Olanzapine for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review to Identify the Best Way to Administer the Drug
文献类型：期刊论文
| 作者 | Zhang, Xiao-Ling2; Ying, Jie-Er1 |
| 刊名 | CURRENT ONCOLOGY
 |
| 出版日期 | 2022-11-01 |
| 卷号 | 29 |
| 关键词 | olanzapine CINV mechanism dosage time routes |
| ISSN号 | 1198-0052 |
| DOI | 10.3390/curroncol29110650 |
| 通讯作者 | Ying, Jie-Er(jieerying@aliyun.com) |
| 英文摘要 | Common treatment methods for malignant tumors include surgery, chemotherapy, radiotherapy, immunotherapy, targeted therapy, etc., among which chemotherapy plays an important role. However, chemotherapy brings corresponding side effects while killing tumor cells, and nausea and vomiting are the most common adverse reactions induced by chemotherapy. It not only affects the patient's appetite, resulting in malnutrition and electrolyte disturbances, but also reduces the patient's compliance with treatment, which further aggravates the disease. Thus, it is important to quickly prevent and cure nausea and vomiting induced by chemotherapy (CINV). In addition, with the continuous development of medicine, more and more antiemetic drugs have been developed. At present, the most common antiemetic agents for chemotherapy-induced nausea and vomiting are NK-1R antagonists, 5-HT3R antagonists, and dexamethasone. Surprisingly, olanzapine, often used as a psychotropic drug, has been found to be an effective antiemetic and is similar to other regimens on the safety of medicine. However, although there are numerous studies on the antiemetic effects of olanzapine, its comprehensive application remains unclear. Therefore, this review will elaborate the antiemetic effect of olanzapine in terms of the antiemetic mechanism and the safety, economic cost, dose, administration time, and drug delivery aspects. |
| WOS关键词 | CISPLATIN-BASED CHEMOTHERAPY ; CINV STUDY-GROUP ; DOUBLE-BLIND ; INTRAMUSCULAR OLANZAPINE ; ANTIEMETIC THERAPY ; CANCER-PATIENTS ; PHASE-II ; 5 MG ; EFFICACY ; DEXAMETHASONE |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000881008000001 |
| 出版者 | MDPI |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130335]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Ying, Jie-Er |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 2.Wenzhou Med Univ, Wenzhou 325000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiao-Ling,Ying, Jie-Er. Olanzapine for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review to Identify the Best Way to Administer the Drug[J]. CURRENT ONCOLOGY,2022,29. |
| APA | Zhang, Xiao-Ling,&Ying, Jie-Er.(2022).Olanzapine for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review to Identify the Best Way to Administer the Drug.CURRENT ONCOLOGY,29. |
| MLA | Zhang, Xiao-Ling,et al."Olanzapine for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review to Identify the Best Way to Administer the Drug".CURRENT ONCOLOGY 29(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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