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RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation

文献类型：期刊论文

作者Hao, Wei-Yuan3; Lou, Yan2; Hu, Guo-Ying5; Qian, Chao-Yi3; Liang, Wei-Ren3; Zhao, Jun1; Wang, Xiao-Hong4
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2022-08-06
卷号616
关键词YTHDF1 N-6-methyladenosine Inflammation NLRP3
ISSN号0006-291X
DOI10.1016/j.bbrc.2022.05.076
通讯作者Zhao, Jun(zhaojun_hangzhou@sina.com) ; Wang, Xiao-Hong(xhwang2022@sina.com)
英文摘要N6-methyladenosine (m6A) modification of mRNAs is involved in multiple essential biological processes, dynamically regulated by m6A "writers", "erasers", and "readers". Yet, the detailed functional roles of RNA m6A reader proteins, such as YTHDFs, are largely unknown. Herein we show that YTHDF1 promotes pro-inflammatory IL-1 beta production in macrophages during bacterial infections. YTHDF1 overexpression promotes NLRP3 translation. In vivo knockdown of YTHDF1 facilitates survival in a mouse model of sepsis. Thus, YTHDF1 participates in inflammatory responses and subsequent injuries, serving as a new potential therapeutic target in clinical treatment of inflammatory diseases. (C) 2022 Published by Elsevier Inc.
WOS关键词NUCLEAR-RNA
资助项目Zhejiang Medical Health Science and Technology Program[2021KY561] ; Zhejiang Medical Health Science and Technology Program[2022KY662]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000880287000012
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
资助机构Zhejiang Medical Health Science and Technology Program
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/130345]  
专题中国科学院合肥物质科学研究院
通讯作者Zhao, Jun; Wang, Xiao-Hong
作者单位1.Zhejiang Med & Hlth Grp Hangzhou Hosp, Dept Respirat & Crit Care Med, Zhejiang Canc Hosp, Cooperat Hosp, 1 Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China
2.Zhejiang Med & Hlth Grp Hangzhou Hosp, Dept Intens Care Unit, Zhejiang Canc Hosp, Cooperat Hosp, 1 Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China
3.Chinese Acad Sci, Univ Chinese Acad Sci, Dept InterventCanc Hosp, Zhejiang Canc Hosp,Inst Canc & Basic Med ICBM, 1 East Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China
4.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Canc & Basic Med ICBM, Dept Intestinal Oncol,Canc Hosp,Zhejiang Canc Hos, 1 East Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China
5.Zhejiang Med & Hlth Grp Hangzhou Hosp, Dept Infect Dis, Zhejiang Canc Hosp, Cooperat Hosp, 1 Banshan Rd, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Hao, Wei-Yuan,Lou, Yan,Hu, Guo-Ying,et al. RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2022,616.
APA Hao, Wei-Yuan.,Lou, Yan.,Hu, Guo-Ying.,Qian, Chao-Yi.,Liang, Wei-Ren.,...&Wang, Xiao-Hong.(2022).RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,616.
MLA Hao, Wei-Yuan,et al."RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 616(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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