The Rostral Ventromedial and Lateral Medulla Are the Major Areas Responsive to Lung Cancer Progression among Brainstem Lung-Innervating Nuclei
文献类型：期刊论文
| 作者 | Chen, Mo5; Jiao, Yingfu4; Shi, Yumiao4; Xu, Saihong4; Tang, Dan4; Chen, Sihan4; Gao, Po4; Zhang, Xindi3; Zhao, Xiaojing3; Cai, Mengmeng2 |
| 刊名 | BRAIN SCIENCES
 |
| 出版日期 | 2022-11-01 |
| 卷号 | 12 |
| 关键词 | lung cancer brain-lung axis crosstalk brainstem nuclei vagal core c-Fos pseudorabies virus retrograde tracing neural circuit |
| DOI | 10.3390/brainsci12111486 |
| 通讯作者 | Yu, Weifeng(ywf808@yeah.net) ; Xie, Kangjie(xiekj9261@126.com) |
| 英文摘要 | In recent years, the information crosstalk between the central nervous system and the periphery has been a hot topic, such as the brain-gut axis, brain-lung axis, etc. Among them, some studies have shown that brainstem nuclei activity can significantly affect the progression of peripheral tumor; however, regarding lung cancer, our understanding of the basic characteristics of the lung-innervating brain nuclei responsive to lung cancer progression remains deficient. Therefore, we used the pseudorabies virus for retrograde labeling of nerves to study the neural circuits between the lung and brain. We then established a mouse orthotopic lung cancer model and used the expression of the c-Fos gene in brain regions to characterize activated brain circuits and compared these results with those of the control group. We focused on c-Fos activity in nuclei associated with retrograde tracing regions of the brainstem. We found over 16 nuclei in the whole brain with direct or indirect lung innervation through neural retrograde labeling with the pseudorabies virus. We further revealed that the neuronal activity of the rostral ventrolateral reticular nucleus (RVL), caudal nucleus of Raphe (raphe obscurus nucleus, ROb), Raphe pallidus nucleus (RPa), and ventral gigantocellular reticular nucleus (GiV) in the rostral ventromedial and lateral medulla were significantly changed in an orthotopic lung cancer mouse model by the immunostaining of c-Fos early responsive protein. Thus, the distinctive rostroventral medulla area, functionally closely related to the vagus nerve, likely plays a role in central neural interaction with peripheral lung tumors and deserves future investigation. |
| WOS关键词 | C1 NEURONS ; PREGANGLIONIC NEURONS ; CNS INNERVATION ; RAPHE OBSCURUS ; PONTINE NUCLEI ; INFLAMMATION ; REFLEX ; NERVE ; STIMULATION ; ACTIVATION |
| 资助项目 | National Key R&D Program of China[2018YFA0108200] ; Shanghai Committee of Science and Technology[19411951900] ; National Natural Science Foundation of China[32030043] ; National Natural Science Foundation of China[82101287] ; Innovative Research Team of High-level Local Universities in Shanghai[SHSMU-ZDCX20211102] ; Shanghai Municipal Key Clinical Specialty[shslczdzk03601] ; Basic PublicWelfare Research Project in Zhejiang Province[LGD20H010001] ; Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation[20DZ2254200] ; Key Specialty Construction Project of Pudong Health and Family Planning Commission of Shanghai[PWZXQ2017-06] ; Innovation Program of Shanghai Municipal Education Commission[2019-01-07-00-01-E00074] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000883440100001 |
| 出版者 | MDPI |
| 资助机构 | National Key R&D Program of China ; Shanghai Committee of Science and Technology ; National Natural Science Foundation of China ; Innovative Research Team of High-level Local Universities in Shanghai ; Shanghai Municipal Key Clinical Specialty ; Basic PublicWelfare Research Project in Zhejiang Province ; Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation ; Key Specialty Construction Project of Pudong Health and Family Planning Commission of Shanghai ; Innovation Program of Shanghai Municipal Education Commission |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130387]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Yu, Weifeng; Xie, Kangjie |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp,Dept Anesthesiol, Canc Hosp,Res Ctr Neuro Oncol Interact,Inst Basic, Hangzhou 310022, Peoples R China 2.Nantong Univ, Nantong Peoples Hosp 1, Dept Anesthesiol, Nantong 226001, Peoples R China 3.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Thorac Surg, Shanghai 200127, Peoples R China 4.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Anesthesiol, Shanghai 200127, Peoples R China 5.Wannan Med Coll, Grad Sch, Wuhu 241000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Mo,Jiao, Yingfu,Shi, Yumiao,et al. The Rostral Ventromedial and Lateral Medulla Are the Major Areas Responsive to Lung Cancer Progression among Brainstem Lung-Innervating Nuclei[J]. BRAIN SCIENCES,2022,12. |
| APA | Chen, Mo.,Jiao, Yingfu.,Shi, Yumiao.,Xu, Saihong.,Tang, Dan.,...&Xie, Kangjie.(2022).The Rostral Ventromedial and Lateral Medulla Are the Major Areas Responsive to Lung Cancer Progression among Brainstem Lung-Innervating Nuclei.BRAIN SCIENCES,12. |
| MLA | Chen, Mo,et al."The Rostral Ventromedial and Lateral Medulla Are the Major Areas Responsive to Lung Cancer Progression among Brainstem Lung-Innervating Nuclei".BRAIN SCIENCES 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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