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Intelligent and robust DNA robots capable of swarming into leakless nonlinear amplification in response to a trigger

文献类型：期刊论文

作者Li, Shaofei1,2,4; Cheng, Yizhuang2,4; Qin, Miao2,4; Zhou, Guoliang2,4; Li, Pan2; Yang, Liangbao2,3
刊名NANOSCALE HORIZONS
出版日期2022-04-22
ISSN号2055-6756
DOI10.1039/d2nh00018k
通讯作者Yang, Liangbao(lbyang@iim.ac.cn)
英文摘要Nonlinear DNA signal amplification with an enzyme-free isothermal self-assembly process is uniquely useful in nanotechnology and nanomedicine. However, progress in this direction is hampered by the lack of effective design models of leak-resistant DNA building blocks. Here, we propose two conceptual models of intelligent and robust DNA robots to perform a leakless nonlinear signal amplification in response to a trigger. Two conceptual models are based on super-hairpin nanostructures, which are designed by innovating novel principles in methodology and codifying them into embedded programs. The dynamical and thermodynamical analyses reveal the critical elements and leak-resistant mechanisms of the designed models, and the leak-resistant behaviors of the intelligent DNA robots and morphologies of swarming into nonlinear amplification are separately verified. The applications of the designed models are also illustrated in specific signal amplification and targeted payload enrichment via integration with an aptamer, a fluorescent molecule and surface-enhanced Raman spectroscopy. This work has the potential to serve as design guidelines of intelligent and robust DNA robots and leakless nonlinear DNA amplification, and also as the design blueprint of cargo delivery robots with the performance of swarming into nonlinear amplification in response to a target automatically, facilitating their future applications in biosensing, bioimaging and biomedicine.
WOS关键词HYBRIDIZATION CHAIN-REACTION ; SINGLE ; KINETICS
资助项目National Science Foundation of China[21974142] ; Natural Science Research Project of Universities in Anhui Province[K120438026] ; Nature Science Research Project of Anhui Province[1908085QB65]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000792246500001
出版者ROYAL SOC CHEMISTRY
资助机构National Science Foundation of China ; Natural Science Research Project of Universities in Anhui Province ; Nature Science Research Project of Anhui Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/130779]  
专题中国科学院合肥物质科学研究院
通讯作者Yang, Liangbao
作者单位1.Anhui Univ, Sch Life Sci, Hefei 230601, Anhui, Peoples R China
2.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China
3.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Anhui, Peoples R China
4.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Li, Shaofei,Cheng, Yizhuang,Qin, Miao,et al. Intelligent and robust DNA robots capable of swarming into leakless nonlinear amplification in response to a trigger[J]. NANOSCALE HORIZONS,2022.
APA Li, Shaofei,Cheng, Yizhuang,Qin, Miao,Zhou, Guoliang,Li, Pan,&Yang, Liangbao.(2022).Intelligent and robust DNA robots capable of swarming into leakless nonlinear amplification in response to a trigger.NANOSCALE HORIZONS.
MLA Li, Shaofei,et al."Intelligent and robust DNA robots capable of swarming into leakless nonlinear amplification in response to a trigger".NANOSCALE HORIZONS (2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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