MFAP2 aggravates tumor progression through activating FOXM1/beta-catenin-mediated glycolysis in ovarian cancer
文献类型：期刊论文
| 作者 | Zhao, Ling-Qin1,2; Sun, Wei1,2; Zhang, Ping1,2; Gao, Wen1,2; Fang, Chen-Yan1,2; Zheng, Ai-Wen1,2 |
| 刊名 | KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
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| 出版日期 | 2022-05-12 |
| 关键词 | CCK-8 FOXM1 GLUT1 microfibril-associated protein 2 (MFAP2) ovarian cancer |
| ISSN号 | 1607-551X |
| DOI | 10.1002/kjm2.12546 |
| 通讯作者 | Zheng, Ai-Wen(zhengaiwen12345@163.com) |
| 英文摘要 | Ovarian cancer is one of the most common gynecological tumors that seriously endanger the health and quality of life of women. Microfibril-associated protein 2 (MFAP2) has been demonstrated to play crucial roles in the development of multiple tumors. However, the function of MFAP2 in ovarian cancer remains unclear. In this study, we found that MFAP2 was upregulated in ovarian cancer and cells and was positively correlated with FOXM1 and glycolysis-related genes. The results of Cell Count Kit-8, colony formation, and flow cytometry assays indicated that MFAP2 promoted cell proliferation. In addition, MFAP2 promotes cell proliferation, glucose uptake, lactate production; increases ATP levels, extracellular acidification ratio, and oxygen consumption ratio in ovarian cancer cells and increases the expression of glycolytic proteins. Further mechanistic analysis suggests that MFAP2 promotes FOXM1/beta-catenin-mediated glycolysis signaling in ovarian cancer cells. Knockdown of MFAP2 inhibits ovarian cancer xenograft tumor growth and expression of Ki-67, MFAP2, FOXM1, GLUT1, HK2, and beta-catenin in mice. In conclusion, MFAP2 promotes cell proliferation and glycolysis by modulating the FOXM1/beta-catenin signaling pathway in ovarian cancer, which may offer a fresh insight into the treatment of ovarian cancer in the glycolysis pathway. |
| WOS关键词 | GASTRIC-CANCER ; FOXM1 PROMOTES ; MICROFIBRILS ; METASTASIS ; METABOLISM ; BIOMARKERS ; CELLS |
| 资助项目 | Medical Science Project of Zhejiang Province[2022KY688] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000793718700001 |
| 出版者 | WILEY |
| 资助机构 | Medical Science Project of Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130821]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zheng, Ai-Wen |
| 作者单位 | 1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Dept Gynecol Oncol, Zhejiang Canc Hosp, East Banshan Rd, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Ling-Qin,Sun, Wei,Zhang, Ping,et al. MFAP2 aggravates tumor progression through activating FOXM1/beta-catenin-mediated glycolysis in ovarian cancer[J]. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES,2022. |
| APA | Zhao, Ling-Qin,Sun, Wei,Zhang, Ping,Gao, Wen,Fang, Chen-Yan,&Zheng, Ai-Wen.(2022).MFAP2 aggravates tumor progression through activating FOXM1/beta-catenin-mediated glycolysis in ovarian cancer.KAOHSIUNG JOURNAL OF MEDICAL SCIENCES. |
| MLA | Zhao, Ling-Qin,et al."MFAP2 aggravates tumor progression through activating FOXM1/beta-catenin-mediated glycolysis in ovarian cancer".KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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