Novel Dual-Signal Electrochemiluminescence Aptasensor Involving the Resonance Energy Transform System for Kanamycin Detection
文献类型：期刊论文
| 作者 | Li, Jingxian3; Luo, Mengyu3; Yang, Hongfen2; Ma, Chao3; Cai, Ren3; Tan, Weihong1,3,4,5 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2022-04-26 |
| 卷号 | 94 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.2c01163 |
| 通讯作者 | Cai, Ren(cairen@hnu.edu.cn) |
| 英文摘要 | Based on luminol-capped Pt-tipped Au bimetallic nanorods (NRs) (L-Au-Pt NRs) as the anode emitter and SnS2 quantum dots (QDs) hybrid Eu metal organic frameworks (MOFs) (SnS(2)QDs@Eu MOFs) as the cathode emitter, a dual-signal electrochemiluminescence (ECL) platform was designed for the ultrasensitive and highly selective detection of kanamycin (KAN). Using a dual-signal output mod; the ratiometric ECL aptasensor largely eliminates false-positives or false-negatives by self-calibration in the KAN assay process. To stimulate the resonance energy transform (RET) system, the KAN aptamer and complementary DNA are introduced for conjugation between the donor and acceptor. With the specific recognition of target KAN by its aptamer, L-Au-Pt NRs-apt partially peels off from the electrode surface. Eventually, the RET system is removed, leading to an increasing cathode signal and a decreasing anode signal. In view of this phenomenon, the ratiometric aptasensor can quantify KAN from 1 pM to 10 nM with a low detection limit of 0.32 pM. This dual-signal ECL aptasensor exhibits great practical potential in environmental monitoring and food safety. |
| WOS关键词 | BIOSENSOR |
| 资助项目 | National Natural Science Foundation of China[22004032] ; Hunan Provincial Natural Science Foundation of China[2021JJ20020] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000792310600041 |
| 资助机构 | National Natural Science Foundation of China ; Hunan Provincial Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130843]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Cai, Ren |
| 作者单位 | 1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Canc Hosp,Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China 2.Univ Texas Austin, Austin, TX 78712 USA 3.Hunan Univ, Coll Mat Sci & Engn, Coll Chem & Chem Engn,Mol Sci & Biomed Lab, Coll Biol,State Key Lab Chemo Biosensing & Chemom, Changsha 410082, Hunan, Peoples R China 4.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jingxian,Luo, Mengyu,Yang, Hongfen,et al. Novel Dual-Signal Electrochemiluminescence Aptasensor Involving the Resonance Energy Transform System for Kanamycin Detection[J]. ANALYTICAL CHEMISTRY,2022,94. |
| APA | Li, Jingxian,Luo, Mengyu,Yang, Hongfen,Ma, Chao,Cai, Ren,&Tan, Weihong.(2022).Novel Dual-Signal Electrochemiluminescence Aptasensor Involving the Resonance Energy Transform System for Kanamycin Detection.ANALYTICAL CHEMISTRY,94. |
| MLA | Li, Jingxian,et al."Novel Dual-Signal Electrochemiluminescence Aptasensor Involving the Resonance Energy Transform System for Kanamycin Detection".ANALYTICAL CHEMISTRY 94(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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