Efficacy and safety of radiotherapy combined with raltitrexed and irinotecan for treating unresectable recurrent colorectal cancer: a single-arm phase II trial
文献类型：期刊论文
| 作者 | Li, Xinghui1,3; Shen, Jinwen2,4,5; Xia, Fan1,3; Zhu, Ji2,4,5 |
| 刊名 | JOURNAL OF GASTROINTESTINAL ONCOLOGY
 |
| 出版日期 | 2022-04-28 |
| 关键词 | Colorectal cancer local recurrence intensity-modulated radiotherapy irinotecan raltitrexed |
| ISSN号 | 2078-6891 |
| DOI | 10.21037/jgo-22-308 |
| 通讯作者 | Xia, Fan(tcxiafan@hotmail.com) ; Zhu, Ji(leoon.zhu@gmail.com) |
| 英文摘要 | Background: Local recurrence of colorectal cancer is associated with poor prognosis and quality of life. For patients not eligible for curative surgery, chemoradiation could be a promising therapeutic option, but there is no consensus yet for the concurrent chemotherapy regimen. This study evaluated the effects and safety of intensity-modulated radiation therapy (IMRT) when administered concurrently with raltitrexed and irinotecan to patients with unresectable recurrent colorectal cancer. Methods: Eligible patients developed unresectable recurrent colorectal cancer, and were refractory to, or intolerant of, chemotherapy with fiuoropyrimidine and oxaliplatin. IMRT was delivered (total dose: 50-60 Gy in 25-30 fractions) concurrently with irinotecan and raltitrexed (200 and 3 mg/m(2), respectively, on days 1 and 22). After treatment completion, patients underwent surgery or continued the same regimen of chemotherapy and were assessed by a multidisciplinary team. The primary endpoint was the objective response rate, defined as the proportion of patients with a confirmed complete response or partial response, assessed by radiologist and investigator after the completion of radiotherapy and reconfirmed a month later, in accordance with the Response Evaluation Criteria in Solid Tumors version 1.1. Results: All 30 patients enrolled in this study between January 2019 and July 2020 completed radiotherapy and received a median of five chemotherapy cycles (range, 2-10 cycles). Twelve patients (40.0%) experienced an objective response (two complete responses and ten partial responses) and 17 patients exhibited stable disease [disease control rate (DCR): 96.7%]. The median follow-up was 22 months (range, 4-35 months), by the end of follow-up, six (20.0%) patients had local failure in the irradiation field, four (13.3%) had regional progression outside the irradiation field, 13 (43.3%) had distant metastasis or metastatic progression and nine (30.0%) died. The median progression-free survival (PFS) and local PFS (LPFS) were 13.5 and 23 months, respectively. The incidence of grade 3 or 4 adverse events was 26.7%, the most common of which was neutropenia (13.3%). Conclusions: IMRT with concurrent raltitrexed and irinotecan is a feasible treatment for unresectable recurrent colorectal cancer, which allows good tumor response and local control with acceptable toxicity profile. |
| WOS关键词 | RECTAL-CANCER ; 2ND-LINE TREATMENT ; LOCAL RECURRENCE ; PLUS IRINOTECAN ; CHEMOTHERAPY ; CHEMORADIATION ; REIRRADIATION ; FLUOROURACIL ; MULTICENTER ; BEVACIZUMAB |
| WOS研究方向 | Oncology ; Gastroenterology & Hepatology |
| 语种 | 英语 |
| WOS记录号 | WOS:000798254300001 |
| 出版者 | AME PUBL CO |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130893]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Xia, Fan; Zhu, Ji |
| 作者单位 | 1.Fudan Univ, Dept Radiat Oncol, Shanghai Canc Ctr, Shanghai 200032, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Peoples R China 3.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou 310000, Peoples R China 5.Zhejiang Key Lab Radiat Oncol, Hangzhou 310022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xinghui,Shen, Jinwen,Xia, Fan,et al. Efficacy and safety of radiotherapy combined with raltitrexed and irinotecan for treating unresectable recurrent colorectal cancer: a single-arm phase II trial[J]. JOURNAL OF GASTROINTESTINAL ONCOLOGY,2022. |
| APA | Li, Xinghui,Shen, Jinwen,Xia, Fan,&Zhu, Ji.(2022).Efficacy and safety of radiotherapy combined with raltitrexed and irinotecan for treating unresectable recurrent colorectal cancer: a single-arm phase II trial.JOURNAL OF GASTROINTESTINAL ONCOLOGY. |
| MLA | Li, Xinghui,et al."Efficacy and safety of radiotherapy combined with raltitrexed and irinotecan for treating unresectable recurrent colorectal cancer: a single-arm phase II trial".JOURNAL OF GASTROINTESTINAL ONCOLOGY (2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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