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A Rationally Designed Building Block of the Putative Magnetoreceptor MagR

文献类型：期刊论文

作者Yang, Peilin2; Cai, Tiantian2; Zhang, Lei3; Yu, Daqi4; Guo, Zhen2; Zhang, Yuebin1; Li, Guohui1; Zhang, Xin3,5; Xie, Can2,3,5,6
刊名BIOELECTROMAGNETICS
出版日期2022-07-01
卷号43
ISSN号0197-8462
关键词magnetoreception MagR rational design single-chain-tetramer building block
DOI10.1002/bem.22413
通讯作者Zhang, Xin(xinzhang@hmfl.ac.cn) ; Xie, Can(canxie@hmfl.ac.cn)
英文摘要The ability of animals to perceive guidance cues from Earth's magnetic field for orientation and navigation has been supported by a wealth of behavioral experiments, yet the nature of this sensory modality remains fascinatingly unresolved and wide open for discovery. MagR has been proposed as a putative magnetoreceptor based on its intrinsic magnetism and its complexation with a previously suggested key protein in magnetosensing, cryptochrome, to form a rod-like polymer structure. Here, we report a rationally designed single-chain tetramer of MagR (SctMagR), serving as the building block of the hierarchical assembly of MagR polymer. The magnetic trapping experiment and direct magnetic measurement of SctMagR demonstrated the possibility of magnetization of nonmagnetic cells via overexpressing a single protein, which has great potential in various applications. SctMagR, as reported in this study, serves as a prototype of designed magnetic biomaterials inspired by animal magnetoreception. The features of SctMagR provide insights into the unresolved origin of the intrinsic magnetic moment, which is of considerable interest in both biology and physics. (c) 2022 Bioelectromagnetics Society.
WOS关键词MOLECULAR CHARACTERIZATION ; EXPRESSION PROFILES ; CRYSTAL-STRUCTURE ; ISCA ; PROTEIN ; CLUSTER ; ORIENTATION ; ANCIENT ; REVEALS ; BINDING
资助项目Presidential Foundation of Hefei Institutes of Physical Science, Chinese Academy of Sciences[BJZX201901] ; HFIPS Director's Fund[YZJJZX202014] ; National Natural Science Foundation of China[31640001] ; National Natural Science Foundation of China[21625302] ; National Natural Science Foundation of China[31700647]
WOS研究方向Life Sciences & Biomedicine - Other Topics ; Biophysics
语种英语
出版者WILEY
WOS记录号WOS:000798526700001
资助机构Presidential Foundation of Hefei Institutes of Physical Science, Chinese Academy of Sciences ; HFIPS Director's Fund ; National Natural Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/130925]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Xin; Xie, Can
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian, Peoples R China
2.Peking Univ, Sch Life Sci, State Key Lab Membrane Biol, Lab Mol Biophys, Beijing, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Peoples R China
4.Peking Univ, Sch Phys, State Key Lab Artificial Microstruct & Mesoscop P, Beijing, Peoples R China
5.Int Magnetobiol Frontier Res Ctr, Hefei, Peoples R China
6.China Acad Engn Phys, Beijing Computat Sci Res Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Peilin,Cai, Tiantian,Zhang, Lei,et al. A Rationally Designed Building Block of the Putative Magnetoreceptor MagR[J]. BIOELECTROMAGNETICS,2022,43.
APA Yang, Peilin.,Cai, Tiantian.,Zhang, Lei.,Yu, Daqi.,Guo, Zhen.,...&Xie, Can.(2022).A Rationally Designed Building Block of the Putative Magnetoreceptor MagR.BIOELECTROMAGNETICS,43.
MLA Yang, Peilin,et al."A Rationally Designed Building Block of the Putative Magnetoreceptor MagR".BIOELECTROMAGNETICS 43(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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