Research on Orientation of Basic Fibroblast Growth Factor with Magnetic Nanoparticles (MNPs) on Regeneration and Recovery of Rats? Dampened Skeletal Muscle and Expressed Level of Matrix Metalloproteinase
文献类型：期刊论文
| 作者 | Jin, Bicheng2; Zhang, Lei1; Wang, Xiaowei3; Jin, Dongfang4 |
| 刊名 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
 |
| 出版日期 | 2022-02-01 |
| 卷号 | 18 |
| 关键词 | MNP bFGF Orientation Skeletal Muscle Contusion Skeletal Muscle Regeneration Recovery Level of MMPS |
| ISSN号 | 1550-7033 |
| DOI | 10.1166/jbn.2022.3260 |
| 通讯作者 | Jin, Dongfang(jingDF2021@126.com) |
| 英文摘要 | The basic fibroblast growth factor (bFGF) has a special role in improving proliferation and differentiation of fiber cells in growth of muscle. The function of bFGF with magnetic nanoparticles (MNPs) on regeneration and recovery of rats' dampened skeletal muscle and expression of MMPS were studied in our research. The MNPs packed with bFGF were prepared and 95 experimental rats were selected. These 30 rats were equally divided into control group, model group (self-healing without obstruction after model was established), bFGF group (disposed with bFGF packaged with MNP). The contractility and stress relaxation of rats' skeletal muscle were observed at the 48th h, 10th, 17th, 24th and 30th days after damage. The remaining 65 rats were divided randomly into control group (5 rats) and experimental group (60 rats intervened with MNPs packaged with bFGF). The groups were randomly divided into 0.5 h, 1 h, 3 h, 6 h, 12 h, 1 d, 2 d, 3 d, 4 d, 7 d, 10 d and 14 d according to different executed time. The levels of bFGF and MMPS were detected by HE staining method and immunohistochemical staining. There was a significant declining tendency of shrinkage stress of muscle in the model, sham-operation, BSA and bFGF groups compared with control group in the second day. The contractility after contusion wound in the regeneration and recovery of rats' skeletal muscle was effectively alleviated with MNPs packaged with bFGF. |
| WOS关键词 | INJURY ; CELLS ; BFGF |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000795074800002 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130939]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Jin, Dongfang |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp,Dept Integrated Chinese & West, Canc Hosp,Inst Basic Med & Canc IBMC,Dept Orthope, Hangzhou 310022, Zhejiang, Peoples R China 2.JinHua Peoples Hosp, Dept Orthoped, Jinhua 321000, Zhejiang, Peoples R China 3.Zhejiang Hosp, Gen Hosp Area, Dept Plast Surg, Hangzhou 310013, Zhejiang, Peoples R China 4.JinHua Peoples Hosp, Dept Clin Lab, Jinhua 321000, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Bicheng,Zhang, Lei,Wang, Xiaowei,et al. Research on Orientation of Basic Fibroblast Growth Factor with Magnetic Nanoparticles (MNPs) on Regeneration and Recovery of Rats? Dampened Skeletal Muscle and Expressed Level of Matrix Metalloproteinase[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2022,18. |
| APA | Jin, Bicheng,Zhang, Lei,Wang, Xiaowei,&Jin, Dongfang.(2022).Research on Orientation of Basic Fibroblast Growth Factor with Magnetic Nanoparticles (MNPs) on Regeneration and Recovery of Rats? Dampened Skeletal Muscle and Expressed Level of Matrix Metalloproteinase.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,18. |
| MLA | Jin, Bicheng,et al."Research on Orientation of Basic Fibroblast Growth Factor with Magnetic Nanoparticles (MNPs) on Regeneration and Recovery of Rats? Dampened Skeletal Muscle and Expressed Level of Matrix Metalloproteinase".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 18(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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