Chronic graft-versus-host disease-related polymyositis and myocarditis: A case report and review of the literature
文献类型：期刊论文
| 作者 | Yan, Mengni2,3; Su, Fengqin2,3; Cheng, Fei1; Shi, Jimin2,3; Zheng, Weiyan2,3; Luo, Yi2,3; Wang, Jianwen1; Lu, Hui1; Zhou, Haiying1; Huang, He2,3
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| 刊名 | TRANSPLANT IMMUNOLOGY
 |
| 出版日期 | 2022-06-01 |
| 卷号 | 72 |
| 关键词 | Hematopoietic stem cell transplantation Chronic graft-versus-host disease Polymyositis Myocarditis |
| ISSN号 | 0966-3274 |
| DOI | 10.1016/j.trim.2022.101598 |
| 通讯作者 | Tan, Yamin(yamin0001@126.com) |
| 英文摘要 | Chronic graft-versus-host disease (cGVHD) is a major late complication of hematopoietic stem cell transplantation (HSCT). Polymyositis (PM) has been reported to be an uncommon presentation of cGVHD. Myocarditis is an even rarer manifestation of cGVHD-associated PM. Here, we report a 38-year-old male patient developed cGVHD-related PM twelve years post-transplantation, which was confirmed by muscle biopsy and immunological study. The presence of pain in the chest area, dynamic changes in the electrocardiogram, as well as elevated troponin and myocardial enzyme levels with improvement after immunotherapy all pointed to cardiac involvement. Ruxolitinib in combination with tachlimus and methylprednisolone successfully treated cGVHD associated PM with myocarditis. The literature on cGVHD-related PM and myocarditis is briefly reviewed. |
| WOS关键词 | MANIFESTATION |
| 资助项目 | National Natural Science Founda-tion of China[81970137] |
| WOS研究方向 | Immunology ; Transplantation |
| 语种 | 英语 |
| WOS记录号 | WOS:000793763900003 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Founda-tion of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130943]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Tan, Yamin |
| 作者单位 | 1.Zhejiang Univ, Affiliated Hosp 1, Sch Med, Hangzhou, Peoples R China 2.Zhejiang Univ, Inst Hematol, Hangzhou, Peoples R China 3.Zhejiang Univ, Bone Marrow Transplantat Ctr, Affiliated Hosp 1, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China 4.Chinese Acad Sci, Hematol Dept, Canc Hosp,Inst Basic Med & Canc IBMC, Univ Chinese Acad Sci,Zhejiang Canc Hosp, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Mengni,Su, Fengqin,Cheng, Fei,et al. Chronic graft-versus-host disease-related polymyositis and myocarditis: A case report and review of the literature[J]. TRANSPLANT IMMUNOLOGY,2022,72. |
| APA | Yan, Mengni.,Su, Fengqin.,Cheng, Fei.,Shi, Jimin.,Zheng, Weiyan.,...&Tan, Yamin.(2022).Chronic graft-versus-host disease-related polymyositis and myocarditis: A case report and review of the literature.TRANSPLANT IMMUNOLOGY,72. |
| MLA | Yan, Mengni,et al."Chronic graft-versus-host disease-related polymyositis and myocarditis: A case report and review of the literature".TRANSPLANT IMMUNOLOGY 72(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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