CDK9 inhibitors in cancer research
文献类型：期刊论文
| 作者 | Huang, Zhi1,2; Wang, Tianqi2; Wang, Cheng2; Fan, Yan2 |
| 刊名 | RSC MEDICINAL CHEMISTRY
 |
| 出版日期 | 2022-04-20 |
| DOI | 10.1039/d2md00040g |
| 通讯作者 | Fan, Yan(yanfan@nankai.edu.cn) |
| 英文摘要 | Cyclin dependent kinase 9 (CDK9) plays an essential role in regulating transcriptional elongation. Aberrations in CDK9 activity have been observed in various cancers, which make CDK9 an attractive therapeutic target for cancers. This led to an intensive development of small-molecule CDK9 inhibitors or new emerging strategies, such as proteolysis targeting chimeras (PROTACs). Here, we review the CDK9 modulators in cancer not only for research purposes, but also for therapeutic applications. |
| WOS关键词 | CYCLIN-DEPENDENT KINASE ; POTENT ANTITUMOR-ACTIVITY ; SINGLE-AGENT ACTIVITY ; CYC202 R-ROSCOVITINE ; IN-VITRO ; CELL-CYCLE ; SELICICLIB CYC202 ; MULTIPLE-MYELOMA ; DOWN-REGULATION ; TARGETING CDK9 |
| 资助项目 | National Natural Science Foundation of China[81903099] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000795942000001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/130959]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Fan, Yan |
| 作者单位 | 1.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China 2.Nankai Univ, Sch Med, Dept Med Chem, 94 Weijin Rd, Tianjin 300071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Zhi,Wang, Tianqi,Wang, Cheng,et al. CDK9 inhibitors in cancer research[J]. RSC MEDICINAL CHEMISTRY,2022. |
| APA | Huang, Zhi,Wang, Tianqi,Wang, Cheng,&Fan, Yan.(2022).CDK9 inhibitors in cancer research.RSC MEDICINAL CHEMISTRY. |
| MLA | Huang, Zhi,et al."CDK9 inhibitors in cancer research".RSC MEDICINAL CHEMISTRY (2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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