Identifying Heterozipper ?-Sheet in Twisted Amyloid Aggregation br
文献类型：期刊论文
| 作者 | Song, Yongxiu3,7,8; Dai, Bin4; Wang, Yong5 ; Wang, Yin8; Liu, Cong1; Gourdon, Pontus2,6; Liu, Lei7; Wang, Kaituo6; Dong, Mingdong8
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| 刊名 | NANO LETTERS
 |
| 出版日期 | 2022-05-11 |
| 卷号 | 22 |
| 关键词 | peptide self-assembly atomic force microscopy cryo-electron microscopy (cryo-EM) hierarchical nanostructure twisted nanofibrils |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.2c00596 |
| 通讯作者 | Liu, Lei(liual@ujs.edu.cn) ; Wang, Kaituo(kaituo@sund.ku.dk) ; Dong, Mingdong(dong@inano.au.dk) |
| 英文摘要 | Amyloid peptide (AP) self-assembly is a hierarch-ical process. However, the mechanistic rule of guiding peptides toorganize well-ordered nanostructure in a clear and precise mannerremains poorly understood. Herein we explored the molecularinsight of AP motif aggregates underlying hierarchical process withhelicalfibrillar structure by atomic force microscope, cryo-electronmicroscopy (cryo-EM), and molecular dynamics simulation. APassembly encompasses well-ordered twistedfibrils with uniformmorphology, size, and periodicity. More importantly, a hetero-zipper beta-sheet was identified in a protofilament of AP assemblydetermined by cryo-EM with a high resolution of 3.5 A. Eachpeptide heterozipper was further composed of two antiparallel beta strands and arranged by an alternative manner in a protofilament.The hydrophobic core and hydrophilic area in each zipper played the significant role for peptide assembling. This work proposedand verified the rule facilitating the basic building unit to form twistedfibrils and gave the explanation of peptide hierarchicalassembling |
| WOS关键词 | PROTEIN SECONDARY STRUCTURE ; DICHROWEB ; PEPTIDE |
| 资助项目 | National Natural Science Foundation of China[22072060] ; National Natural Science Foundation of China[21573097] ; Independent Research Fund Denmark ; EU H2020RISE 2016-MNR4S Cell project ; Zhejiang Province Post-Doctoral Scientific Research Fund[269745] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000801231700028 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Natural Science Foundation of China ; Independent Research Fund Denmark ; EU H2020RISE 2016-MNR4S Cell project ; Zhejiang Province Post-Doctoral Scientific Research Fund |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131039]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Liu, Lei; Wang, Kaituo; Dong, Mingdong |
| 作者单位 | 1.Chinese Acad Sci, Interdisciplinary Res Ctr Biol & Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China 2.Lund Univ, Dept Expt Med Sci, S-22363 Lund, Sweden 3.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Canc Hosp,Zhejiang Canc Hos, Hangzhou 310022, Zhejiang, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Sensing Sci & Engn, Shanghai 200240, Peoples R China 5.Zhejiang Univ, Coll Life Sci, Shanghai Inst Adv Study, Inst Quantitat Biol,Prov Int Sci & Technol Cooper, Int Campus, Haining 314400, Peoples R China 6.Univ Copenhagen, Dept Biomed Sci, DK-2200 Copenhagen, Denmark 7.Jiangsu Univ, Inst Adv Mat, Zhenjiang 212013, Jiangsu, Peoples R China 8.Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus, Denmark |
| 推荐引用方式 GB/T 7714 | Song, Yongxiu,Dai, Bin,Wang, Yong,et al. Identifying Heterozipper ?-Sheet in Twisted Amyloid Aggregation br[J]. NANO LETTERS,2022,22. |
| APA | Song, Yongxiu.,Dai, Bin.,Wang, Yong.,Wang, Yin.,Liu, Cong.,...&Dong, Mingdong.(2022).Identifying Heterozipper ?-Sheet in Twisted Amyloid Aggregation br.NANO LETTERS,22. |
| MLA | Song, Yongxiu,et al."Identifying Heterozipper ?-Sheet in Twisted Amyloid Aggregation br".NANO LETTERS 22(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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