Tumor-infiltrating lymphocytes-based subtypes and genomic characteristics of EBV-associated lymphoepithelioma-like carcinoma
文献类型：期刊论文
| 作者 | Yin, WenJuan1,2; Jin, JiaoYue1,2; Bao, Hua3; Chen, HanLin3; Wang, CanMing1,2; Cheng, GuoPing1,2; Wu, ChaoQi1,2; Wu, Meijuan1,2; Yan, Junrong3; Wu, Xue3 |
| 刊名 | JOURNAL OF PATHOLOGY
 |
| 出版日期 | 2022-05-20 |
| 关键词 | lymphoepithelioma-like carcinomas TILs quantification classification whole exome sequencing targeted therapy |
| ISSN号 | 0022-3417 |
| DOI | 10.1002/path.5916 |
| 通讯作者 | Su, Dan(sudan@zjcc.org.cn) |
| 英文摘要 | Tumor-infiltrating lymphocytes (TILs) offer a key for morphological diagnosis of lymphoepithelioma-like carcinoma (LELC) and are the foundation of oncoimmunology. To date, no reports have found a specific risk stratification value of TILs and related it to genomic variation in LELC. Based on the stromal TILs (str-TILs) ratio, we classified 105 Epstein-Barr virus (EBV)-associated LELC cases into two subtypes: patients with >= 60% str-TILs area ratio in tumor were classified as subtype I, and otherwise as subtype II. Subtype I patients had significantly better progression-free survival (PFS) and overall survival (OS). We also explored the genomic characteristics of EBV-associated LELC within different involved organs. We performed whole-exome sequencing for 51 patients with enough tissue and analyzed the genomic characteristics of EBV-associated LELC. Overall, EBV-associated LELCs were characterized by a low somatic mutation rate and copy number variations; the enriched genetic lesions affected RTK-RAS, PI3K, and cell cycle pathways. Moreover, EBV-associated LELCs from different organs were more similar to each other genetically as compared with other traditional carcinomas of the same sites?as evidenced by unsupervised clustering based on the quantitative data from both mutation signature and chromosomal aneuploidies. Notably, EBV-associated LELC patients with oncogenic driver alterations showed a worse prognosis compared with patients without such alterations. (c) 2022 The Pathological Society of Great Britain and Ireland. |
| WOS关键词 | EPSTEIN-BARR-VIRUS ; EXPRESSION |
| 资助项目 | Key Research and Development Projects - Ministry of Science and Technology of Zhejiang Province[2020C03023] ; High-Level Creative and Innovative Health Talent Program of Zhejiang Province |
| WOS研究方向 | Oncology ; Pathology |
| 语种 | 英语 |
| WOS记录号 | WOS:000799491800001 |
| 出版者 | WILEY |
| 资助机构 | Key Research and Development Projects - Ministry of Science and Technology of Zhejiang Province ; High-Level Creative and Innovative Health Talent Program of Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131063]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Su, Dan |
| 作者单位 | 1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Dept Pathol, Zhejiang Canc Hosp, Hangzhou, Peoples R China 3.Nanjing Geneseeq Technol Inc, Nanjing, Peoples R China 4.Nanjing Med Univ, Sch Publ Hlth, Nanjing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, WenJuan,Jin, JiaoYue,Bao, Hua,et al. Tumor-infiltrating lymphocytes-based subtypes and genomic characteristics of EBV-associated lymphoepithelioma-like carcinoma[J]. JOURNAL OF PATHOLOGY,2022. |
| APA | Yin, WenJuan.,Jin, JiaoYue.,Bao, Hua.,Chen, HanLin.,Wang, CanMing.,...&Su, Dan.(2022).Tumor-infiltrating lymphocytes-based subtypes and genomic characteristics of EBV-associated lymphoepithelioma-like carcinoma.JOURNAL OF PATHOLOGY. |
| MLA | Yin, WenJuan,et al."Tumor-infiltrating lymphocytes-based subtypes and genomic characteristics of EBV-associated lymphoepithelioma-like carcinoma".JOURNAL OF PATHOLOGY (2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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