Cholecalciferol pretreatment ameliorates ischemia/reperfusion-induced acute kidney injury through inhibiting ROS production, NF-KB pathway and pyroptosis
文献类型：期刊论文
| 作者 | Wu, Wangyu3; Liu, Dongyan1,2; Zhao, Yuxiang3; Zhang, Taotao3; Ma, Jiaxing3; Wang, Dengdian3; Li, Jun3; Qian, Weiwei3; Zhang, Zhihui3; Yu, Dexin3 |
| 刊名 | ACTA HISTOCHEMICA
 |
| 出版日期 | 2022-05-01 |
| 卷号 | 124 |
| ISSN号 | 0065-1281 |
| 关键词 | Acute kidney injury Ischemia and reperfusion Cholecalciferol ROS NF-KB pathway Pyroptosis |
| DOI | 10.1016/j.acthis.2022.151875 |
| 通讯作者 | Zhang, Tao(zhangtao@ahmu.edu.cn) |
| 英文摘要 | Acute kidney injury (AKI) is a common complication in patients with potentially life-threatening diseases, and it is also usually associated with unacceptable morbidity and mortality rates. Therefore, new and efficient therapies are urgently required to relieve AKI. It is well known that, reactive oxygen species (ROS), the NF-KB signaling pathways and pyroptosis are involved in AKI induced by ischemia/reperfusion (I/R). The present study seeks to further confirm the internal relationship between vitamin D deficiency and I/R-induced AKI in patients, and to explore the underlying mechanisms of ROS, NF-KB signaling pathways and pyroptosis in the renal ischemiareperfusion injury, as well as investigating the protective role of cholecalciferol. Patients with vitamin D deficiency show worse renal function reflected by postoperative glomerular filtration rate (GFR) and more release of proinflammatory cytokine IL-18 and IL-18. Renal cell injury and renal dysfunction induced by I/R surgery were attenuated in the ICR mice administered with cholecalciferol. Cholecalciferol reduced ROS production, suppressed activated NF-KB signaling, and inhibited gasdermin D (GSDMD, a pyroptosis execution protein)-mediated pyroptosis. Cholecalciferol therefore has potential, as a clinical drug, to protect renal function in I/R-induced AKI through reducing ROS production, NF-KB activation and GSDMD-mediated pyroptosis. |
| 资助项目 | scientific research and Experiment Center of the Second Hospital of Anhui Medical University ; Doctoral Start-up Foundation of the Second Affiliated Hospital of Anhui Medical University[2018BSJJ012] ; Provincial Natural Science Foundation of Anhui, China[2008085MH290] ; Key projects of Provincial Natural Science Foundation of Colleges and Universities in Anhui, China[KJ2018A0209] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| 出版者 | ELSEVIER GMBH |
| WOS记录号 | WOS:000807362700001 |
| 资助机构 | scientific research and Experiment Center of the Second Hospital of Anhui Medical University ; Doctoral Start-up Foundation of the Second Affiliated Hospital of Anhui Medical University ; Provincial Natural Science Foundation of Anhui, China ; Key projects of Provincial Natural Science Foundation of Colleges and Universities in Anhui, China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131231]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Tao |
| 作者单位 | 1.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Peoples R China 3.Anhui Med Univ, Dept Urol, Affiliated Hosp 2, Hefei 230601, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Wangyu,Liu, Dongyan,Zhao, Yuxiang,et al. Cholecalciferol pretreatment ameliorates ischemia/reperfusion-induced acute kidney injury through inhibiting ROS production, NF-KB pathway and pyroptosis[J]. ACTA HISTOCHEMICA,2022,124. |
| APA | Wu, Wangyu.,Liu, Dongyan.,Zhao, Yuxiang.,Zhang, Taotao.,Ma, Jiaxing.,...&Zhang, Tao.(2022).Cholecalciferol pretreatment ameliorates ischemia/reperfusion-induced acute kidney injury through inhibiting ROS production, NF-KB pathway and pyroptosis.ACTA HISTOCHEMICA,124. |
| MLA | Wu, Wangyu,et al."Cholecalciferol pretreatment ameliorates ischemia/reperfusion-induced acute kidney injury through inhibiting ROS production, NF-KB pathway and pyroptosis".ACTA HISTOCHEMICA 124(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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