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Novel carboxymethyl chitosan/N-acetylneuraminic acid hydrogel for the protection of Pediococcus pentosaceus

文献类型：期刊论文

作者Ge, Yuanfei1,3; Wu, Jinyong1; Pang, Min2; Hu, Dan1,3; Li, Zhongkui1; Wang, Xiangqin1; Sun, Lijie1; Chen, Xiangsong1; Yao, Jianming1,3
刊名FOOD RESEARCH INTERNATIONAL
出版日期2022-06-01
卷号156
关键词Carboxymethyl chitosan N-acetylneuraminic acid Hydrogel Encapsulation Pediococcus pentosaceus
ISSN号0963-9969
DOI10.1016/j.foodres.2022.111355
通讯作者Chen, Xiangsong(xschen@ipp.cas.cn) ; Yao, Jianming(jmyaocas@163.com)
英文摘要In this study, carboxymethyl chitosan (CMCS) and N-acetylneuraminic acid (NeuAc) were used to develop CNeuAc hydrogels to encapsulate Pediococcus pentosaceus QK-1. The mechanical properties, thermal stability, in vitro degradation, and pH sensitivity of the hydrogel were evaluated. The C-NeuAc concentration required for optimal hydrogel performance was 3% (w/v). Hydrogel swelling behaviour was effectively assessed by Fickian diffusion and Schott's second-order kinetic models. The hydrogel demonstrated excellent biocompatibility and low in vitro cytotoxicity. An in vitro assay revealed that the viability of Pediococcus pentosaceus QK-1 in C-NeuAc had decreased by only 1.41 log (CFU/ mL) after exposure to simulated acidic gastric fluid. Moreover, the survival rate of the encapsulated and free Pediococcus pentosaceus QK-1 cells were 80.1% and virtually zero, respectively, after passage through the gastrointestinal tract. It was empirically determined that low temperature and freezedrying were the ideal condition and method to ensure storage longevity of the hydrogel-encapsulated probiotic. Hence, C-NeuAc hydrogel is highly desirable as a food-grade probiotic delivery vehicle.
WOS关键词NEURAMINIC ACID ; NANOCOMPOSITES ; ADSORPTION ; PH
资助项目postdoctoral research funding project of Anhui province[2020B440] ; Special Project of Science and Technology Cooperation between Hubei Province and Chinese Academy of Sciences[2021-01-09] ; Wuhan Science and Technology Plan Project Enterprise Technology Innovation Special Project[2020020602012119]
WOS研究方向Food Science & Technology
语种英语
WOS记录号WOS:000810383900011
出版者ELSEVIER
资助机构postdoctoral research funding project of Anhui province ; Special Project of Science and Technology Cooperation between Hubei Province and Chinese Academy of Sciences ; Wuhan Science and Technology Plan Project Enterprise Technology Innovation Special Project
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/131261]  
专题中国科学院合肥物质科学研究院
通讯作者Chen, Xiangsong; Yao, Jianming
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Plasma Phys, Hefei 230031, Peoples R China
2.Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230601, Peoples R China
3.Univ Sci & Technol China, Hefei 230026, Peoples R China
推荐引用方式
GB/T 7714		 Ge, Yuanfei,Wu, Jinyong,Pang, Min,et al. Novel carboxymethyl chitosan/N-acetylneuraminic acid hydrogel for the protection of Pediococcus pentosaceus[J]. FOOD RESEARCH INTERNATIONAL,2022,156.
APA Ge, Yuanfei.,Wu, Jinyong.,Pang, Min.,Hu, Dan.,Li, Zhongkui.,...&Yao, Jianming.(2022).Novel carboxymethyl chitosan/N-acetylneuraminic acid hydrogel for the protection of Pediococcus pentosaceus.FOOD RESEARCH INTERNATIONAL,156.
MLA Ge, Yuanfei,et al."Novel carboxymethyl chitosan/N-acetylneuraminic acid hydrogel for the protection of Pediococcus pentosaceus".FOOD RESEARCH INTERNATIONAL 156(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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