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Stress in DNA Gridiron Facilitates the Formation of Two-Dimensional Crystalline Structures

文献类型：期刊论文

作者Yu, Lei2,3,4; Cheng, Jin1; Wang, Dongfang2,3; Pan, Victor2,3; Chang, Shuai4; Song, Jie1,5,6; Ke, Yonggang2,3
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
出版日期2022-06-08
卷号144
ISSN号0002-7863
DOI10.1021/jacs.2c02009
通讯作者Chang, Shuai(schang23@wust.edu.cn) ; Song, Jie(sjie@sjtu.edu.cn) ; Ke, Yonggang(yonggang.ke@emory.edu)
英文摘要Programmable DNA nanotechnology has generated some of the most intricate self-assembled nanostructures and has been employed in a growing number of applications, including functional nanomaterials, nanofabrication, biophysics, photonics, molecular machines, and drug delivery. An important design rule for DNA nanostructures is to minimize the mechanical stress to reduce the potential energy in these nanostructures whenever it is possible. This work revisits the DNA gridiron design consisting of Holliday junctions and compares the self-assembly of the canonical DNA gridiron with a new design of DNA gridiron, which has a higher degree of mechanical stress because of the interweaving of DNA helices. While the interweaving DNA gridiron indeed exhibits lower yield, compared to its canonical counterpart of a similar size, we discover that the mechanical stress within the interweaving gridiron can promote the formation of the twodimensional crystalline lattice instead of nanotubes. Furthermore, tuning the design of interweaving gridiron leads to the change of overall crystal size and regularity of geometry. Interweaving DNA double helices represents a new design strategy in the self-assembly of DNA nanostructures. Furthermore, the discovery of the new role of mechanical stress in the self-assembly of DNA nanostructures provides useful knowledge to DNA nanotechnology practitioners: a more balanced view regarding mechanical stress can be considered when designing future DNA nanostructures.
WOS关键词FOLDING DNA ; DESIGN ; ORIGAMI ; ARRAYS
资助项目National Science Foundation[DMR-1654485] ; Outstanding Young and Middle-aged Team in Colleges of Hubei Province of China[T2021002] ; National Natural Science Foundation of China[22161132008] ; Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study[SN-ZJU-SIAS-006]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000809993400001
资助机构National Science Foundation ; Outstanding Young and Middle-aged Team in Colleges of Hubei Province of China ; National Natural Science Foundation of China ; Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/131271]  
专题中国科学院合肥物质科学研究院
通讯作者Chang, Shuai; Song, Jie; Ke, Yonggang
作者单位1.Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, Dept Instrument Sci & Engn, Inst Nano Biomed & Engn, Shanghai 200240, Peoples R China
2.Emory Univ, Atlanta, GA 30322 USA
3.Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30322 USA
4.Wuhan Univ Sci & Technol, Inst Adv Mat & Nanotechnol, State Key Lab Refractories & Met, Wuhan 430081, Hubei, Peoples R China
5.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
6.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Lei,Cheng, Jin,Wang, Dongfang,et al. Stress in DNA Gridiron Facilitates the Formation of Two-Dimensional Crystalline Structures[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2022,144.
APA Yu, Lei.,Cheng, Jin.,Wang, Dongfang.,Pan, Victor.,Chang, Shuai.,...&Ke, Yonggang.(2022).Stress in DNA Gridiron Facilitates the Formation of Two-Dimensional Crystalline Structures.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,144.
MLA Yu, Lei,et al."Stress in DNA Gridiron Facilitates the Formation of Two-Dimensional Crystalline Structures".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 144(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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