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A Portable Sensing Platform Using an Upconversion-Based Nanosensor for Visual Quantitative Monitoring of Mesna

文献类型：期刊论文

作者Hu, Bin1,3; Zhu, Jiawei1,3; Shen, Jianjun1,3; Yang, Liang1,2; Jiang, Changlong1,2
刊名ANALYTICAL CHEMISTRY
出版日期2022-05-31
卷号94
ISSN号0003-2700
DOI10.1021/acs.analchem.2c00380
通讯作者Yang, Liang(yangliang@iim.ac.cn) ; Jiang, Changlong(cljiang@iim.ac.cn)
英文摘要Mesna is an important regional antidote for protecting the urinary system of chemotherapy patients, which requires monitoring its level in real time to ensure the curative effect. The fluorescence method is a powerful tool in real-time detection with the advantages of fast response and visualization. However, the background interference limits its application in biological sensing. Here, we developed a portable sensing platform using an upconversion-based nano-sensor for visual quantitative monitoring of mesna in real-time/on-site conditions. The nanosensor was constructed by upconversion nanoparticles (UCNPs) and ethyl violet (EV), in which the UCNPs emitted red and green light, while EV quenched the green light due to the inner filter effect (IFE). The reaction of mesna with EV caused its fading and broke the IFE process, leading to the recovery of green light. By the fluorescence and colorimetric chromaticity variations, the nanosensor achieved a dual-readout detection for mesna with low limits of detection (LODs) of 26 and 48 nM, respectively. Furthermore, a highly compatible sensing platform was fabricated for facile determination of mesna with an LOD of 56 nM, realizing visual quantitative monitoring of the mesna level to ensure the curative effect and providing a new strategy for point-of-care testing of drugs in clinical settings.
WOS关键词INDUCED HEMORRHAGIC CYSTITIS ; REACTIVE OXYGEN ; CYCLOPHOSPHAMIDE ; DOXORUBICIN ; IFOSFAMIDE ; TISSUE ; ACID
资助项目National Natural Science Foundation of China[21876175] ; National Key Research and Development Program[2021YFD2000200] ; Key Research and Development Program of Anhui Province[202004d07020013]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000807338400015
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; National Key Research and Development Program ; Key Research and Development Program of Anhui Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/131277]  
专题中国科学院合肥物质科学研究院
通讯作者Yang, Liang; Jiang, Changlong
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Hefei 230031, Anhui, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Photovolta & Energy Conservat Mat, Hefei 230031, Peoples R China
3.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Bin,Zhu, Jiawei,Shen, Jianjun,et al. A Portable Sensing Platform Using an Upconversion-Based Nanosensor for Visual Quantitative Monitoring of Mesna[J]. ANALYTICAL CHEMISTRY,2022,94.
APA Hu, Bin,Zhu, Jiawei,Shen, Jianjun,Yang, Liang,&Jiang, Changlong.(2022).A Portable Sensing Platform Using an Upconversion-Based Nanosensor for Visual Quantitative Monitoring of Mesna.ANALYTICAL CHEMISTRY,94.
MLA Hu, Bin,et al."A Portable Sensing Platform Using an Upconversion-Based Nanosensor for Visual Quantitative Monitoring of Mesna".ANALYTICAL CHEMISTRY 94(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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