CD3D Is an Independent Prognostic Factor and Correlates With Immune Infiltration in Gastric Cancer
文献类型：期刊论文
| 作者 | Yuan, Li2,3,7; Xu, Jingli4; Shi, Yunfu4; Jin, Zhiyuan7; Bao, Zhehan4; Yu, Pengcheng4; Wang, Yi4 ; Xia, Yuhang4; Qin, Jiangjiang2,3,7; Zhang, Bo1
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| 刊名 | FRONTIERS IN ONCOLOGY
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| 出版日期 | 2022-06-01 |
| 卷号 | 12 |
| ISSN号 | 2234-943X |
| 关键词 | gastric cancer cd3d tumor infiltrating lymphocytes (TILs) prognosis PD-L1 |
| DOI | 10.3389/fonc.2022.913670 |
| 通讯作者 | Qin, Jiangjiang(jqin@ucas.ac.cn) ; Zhang, Bo(zhangbo1705@zjcc.org.cn) ; Yao, Qinghua(yaoqh@zjcc.org.cn) |
| 英文摘要 | The protein encoded by CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. Previous studies have shown that CD3D is associated with prognosis and treatment response in breast, colorectal, and liver cancer. However, the expression and clinical significance of CD3D in gastric cancer are not clear. In this study, we collected 488 gastric cancer tissues and 430 paired adjacent tissues to perform tissue microarrays (TMAs). Then, immunohistochemical staining of CD3D, CD3, CD4, CD8 and PD-L1 was conducted to investigate the expression of CD3D in gastric cancer and the correlation between the expression of CD3D and tumor infiltrating lymphocytes (TILs) and PD-L1. The results showed that CD3D was highly expressed in gastric cancer tissues compared with paracancerous tissues (P<0.000). Univariate and multivariate analyses showed that CD3D was an independent good prognostic factor for gastric cancer (P=0.004, HR=0.677, 95%CI: 0.510-0.898 for univariate analyses; P=0.046, HR=0.687, 95%CI: 0.474-0.994 for multivariate analyses). In addition, CD3D was negatively correlated with the tumor location, Borrmann type and distant metastasis (P=0.012 for tumor location; P=0.007 for Borrmann type; P=0.027 for distant metastasis). In addition, the expression of CD3D was highly positively correlated with the expression of CD3, CD4, CD8, and PD-L1, and the combination of CD3D with CD3, CD4, CD8 and PD-L1 predicted the best prognosis (P=0.043). In summary, CD3D may play an important regulatory role in the tumor immune microenvironment of gastric cancer and may serve as a potential indicator of prognosis and immunotherapy response. |
| WOS关键词 | PREDICTS ; EXPRESSION ; SURVIVAL ; LYMPHOCYTES |
| 资助项目 | National Key R&D Program of China[2021YFA0910100] ; Natural Science Foundation of Zhejiang Province[HDMY22H160008] ; Program of Zhejiang Provincial TCM Scitech Plan[2018ZY006] ; Medical Science and Technology Project of Zhejiang Province ([2022KY114] ; Medical Science and Technology Project of Zhejiang Province ([WKJ-ZJ-2104] ; Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer[JBZX-202006] ; Science and Technology Projects of Zhejiang Province[2019C03049] ; National Natural Science Foundation of China[82074245] ; National Natural Science Foundation of China[81973634] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000811907000001 |
| 资助机构 | National Key R&D Program of China ; Natural Science Foundation of Zhejiang Province ; Program of Zhejiang Provincial TCM Scitech Plan ; Medical Science and Technology Project of Zhejiang Province ( ; Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer ; Science and Technology Projects of Zhejiang Province ; National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131305]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Qin, Jiangjiang; Zhang, Bo; Yao, Qinghua |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Chinese Acad Sci,Canc Hosp,Dept Integrated Chinese, Hangzhou, Peoples R China 2.Zhejiang Canc Hosp, Zhejiang Prov Res Ctr Upper Gastrointestinal Tract, Hangzhou, Peoples R China 3.Zhejiang Canc Hosp, Zhejiang Key Lab Prevent, Diag & Therapy Upper Gastrointestinal Canc, Hangzhou, Peoples R China 4.Zhejiang Chinese Med Univ, Clin Med Coll 1, Hangzhou, Peoples R China 5.Zhejiang Canc Hosp, Key Lab Tradit Chinese Med Oncol, Hangzhou, Peoples R China 6.Key Lab Head & Neck Canc Translat Res Zhejiang Pro, Hangzhou, Peoples R China 7.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Chinese Acad Sci,Canc Hosp, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Li,Xu, Jingli,Shi, Yunfu,et al. CD3D Is an Independent Prognostic Factor and Correlates With Immune Infiltration in Gastric Cancer[J]. FRONTIERS IN ONCOLOGY,2022,12. |
| APA | Yuan, Li.,Xu, Jingli.,Shi, Yunfu.,Jin, Zhiyuan.,Bao, Zhehan.,...&Yao, Qinghua.(2022).CD3D Is an Independent Prognostic Factor and Correlates With Immune Infiltration in Gastric Cancer.FRONTIERS IN ONCOLOGY,12. |
| MLA | Yuan, Li,et al."CD3D Is an Independent Prognostic Factor and Correlates With Immune Infiltration in Gastric Cancer".FRONTIERS IN ONCOLOGY 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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