Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy
文献类型：期刊论文
| 作者 | Zhu, Yong-fu2,3; Wang, Shu-Jie4; Zhou, Jie3; Sun, Ye-han2; Chen, You-mou2; Ma, Jia2; Huo, Xing-xing5; Song, Hang1 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2022-05-30 |
| 卷号 | 12 |
| 关键词 | RNA modifications N6-methyladenosine female malignancies molecular mechanisms immunotherapy |
| ISSN号 | 2234-943X |
| DOI | 10.3389/fonc.2022.897895 |
| 通讯作者 | Huo, Xing-xing(hxx0520@ahtcm.edu.cn) ; Song, Hang(hangsong@ahtcm.edu.cn) |
| 英文摘要 | N-6-methyladenosine (m(6)A) is a major internal epigenetic modification in eukaryotic mRNA, which is dynamic and reversible. m(6)A is regulated by methylases ("writers") and demethylases ("erasers") and is recognized and processed by m(6)A-binding proteins ("readers"), which further regulate RNA transport, localization, translation, and degradation. It plays a role in promoting or suppressing tumors and has the potential to become a therapeutic target for malignant tumors. In this review, we focus on the mutual regulation of m(6)A and coding and non-coding RNAs and introduce the molecular mechanism of m(6)A methylation involved in regulation and its role in cancer treatment by taking common female malignant tumors as an example. |
| WOS关键词 | INHIBITS CELL-PROLIFERATION ; CERVICAL-CANCER ; M(6)A MODIFICATION ; NONCODING RNAS ; METHYLATION ; TRANSLATION ; METASTASIS ; APOPTOSIS ; BINDING ; ROLES |
| 资助项目 | National Natural Science Foundation of China[81802103] ; National Natural Science Foundation of China[81803938] ; Project of High-Level Talents in AHUTCM[2019rcZD001] ; Excellent Young Scholars Project of Natural Science Foundation of Anhui Province in China[2108085Y29] ; Natural Science Research Project of Colleges and Universities in Anhui Province[KJ2021A0557] ; Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Chinese Traditional Medicine) ; Zhejiang Chinese Medical University[ZYXZD2019004] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000810217800001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; Project of High-Level Talents in AHUTCM ; Excellent Young Scholars Project of Natural Science Foundation of Anhui Province in China ; Natural Science Research Project of Colleges and Universities in Anhui Province ; Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Chinese Traditional Medicine) ; Zhejiang Chinese Medical University |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131321]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Huo, Xing-xing; Song, Hang |
| 作者单位 | 1.Anhui Univ Chinese Med, Sch Integrated Chinese & Western Med, Dept Biochem & Mol Biol, Hefei, Peoples R China 2.Anhui Univ Chinese Med, Dept Oncol 1, Affiliated Hosp 1, Hefei, Peoples R China 3.Zhejiang Chinese Med Univ, Dept Acupuncture, Affiliated Hosp 3, Hangzhou, Peoples R China 4.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei, Peoples R China 5.Anhui Univ Chinese Med, Affiliated Hosp 1, Expt Ctr Clin Res, Sci Res Dept, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Yong-fu,Wang, Shu-Jie,Zhou, Jie,et al. Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy[J]. FRONTIERS IN ONCOLOGY,2022,12. |
| APA | Zhu, Yong-fu.,Wang, Shu-Jie.,Zhou, Jie.,Sun, Ye-han.,Chen, You-mou.,...&Song, Hang.(2022).Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy.FRONTIERS IN ONCOLOGY,12. |
| MLA | Zhu, Yong-fu,et al."Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy".FRONTIERS IN ONCOLOGY 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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