Associations Between Serum Reproductive Hormone Concentrations and Hormonal Receptor Status Among Postmenopausal Chinese Women With Breast Cancer: An Observational Study
文献类型：期刊论文
| 作者 | Jiang, Chuner1,5; Wu, Peng1,2; He, Xiangming1,5; Ni, Jianfen1,5; Ding, Xiaowen1,5; Xu, Xiaohong1,3; Wang, Fangzheng1,4; Zou, Dehong1,5 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2022-05-30 |
| 卷号 | 12 |
| ISSN号 | 2234-943X |
| 关键词 | breast cancer postmenopausal reproductive hormones estrogen receptor progesterone receptor HER2 receptor |
| DOI | 10.3389/fonc.2022.819756 |
| 通讯作者 | Wang, Fangzheng(wangfz@zjcc.org.cn) ; Zou, Dehong(zoudh1964@126.com) |
| 英文摘要 | Background and ObjectivesReproductive hormones and receptors play crucial roles in breast cancer development and progression. The association between preoperative serum reproductive hormone levels and receptor status in postmenopausal women with breast cancer remains unclear. Therefore, this study investigated the relationship between serum reproductive hormone concentrations and patient characteristics and hormone receptor status among postmenopausal Chinese women with breast cancer. Materials and MethodsThe medical records of 352 postmenopausal breast cancer patients who underwent an operation between October 2007 and October 2010 at the Department of Breast Tumor Surgery of Zhejiang Cancer Hospital were retrospectively evaluated. Serum levels of reproductive hormones were measured before surgery by liquid-chromatography tandem mass spectrometry. Hormone receptor levels were measured by an immunohistochemical assay using a mouse monoclonal antibody. The associations between serum hormone concentrations and hormone receptors were investigated by analysis of covariance. ResultsIn this patient cohort, the serum level of luteinizing hormone (LH) declined with PMP duration. The median LH concentration was significantly higher in patients within 5 years of PMP than that in patients with PMP duration exceeding 5 years (23 vs. 18.32 mIU/ml, P <.0001). Significantly more patients with strong estrogen receptor (ER) or progesterone receptor (PR) expression had postmenopausal durations of less than 5 years compared to those with postmenopausal durations greater than 5 years (103 vs. 61 cases, P = .019; 93 vs. 46 cases, P = .0005). While most patients either lacked (97.1%) or co-expressed (84.3%) ER and PR, some patients expressed either ER or PR alone. ER and PR expression were negatively associated with receptor-tyrosine kinase erbB-2 (HER2) expression in postmenopausal patients with breast cancer. Meanwhile, increased ER and PR expression were associated with decreased serum levels of LH or follicle-stimulating hormone (FSH). ConclusionDecreased serum LH and FSH levels were associated with increased ER and PR expressions and decreased HER2 expression in postmenopausal patients with breast cancer. |
| WOS关键词 | PROGESTERONE-RECEPTORS ; ESTROGEN ; STATISTICS ; IMMUNOHISTOCHEMISTRY ; MARKERS ; DISEASE ; RISK |
| 资助项目 | Medical and Health Science and Technology Program of Zhejiang Province[2020KY084] ; Medical and Health Science and Technology Program of Zhejiang Province[2019KY041] ; Medical and Health Science and Technology Program of Zhejiang Province[2011RCA014] ; Medical and Health Science and Technology Program of Zhejiang Province[2006A016] ; Medical and Health Science and Technology Program of Zhejiang Province[2005B012] ; National Natural Science Foundation of Zhejiang Province of China[LY15H1800012015] ; National Natural Science Foundation of China[81502646] ; National Natural Science Foundation of China[81502647] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000811323700001 |
| 资助机构 | Medical and Health Science and Technology Program of Zhejiang Province ; National Natural Science Foundation of Zhejiang Province of China ; National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131341]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Fangzheng; Zou, Dehong |
| 作者单位 | 1.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Pathol Dept, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Clin Lab, Hangzhou, Peoples R China 4.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Dept Radiat Oncol, Hangzhou, Peoples R China 5.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Dept Breast Tumor Surg, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Chuner,Wu, Peng,He, Xiangming,et al. Associations Between Serum Reproductive Hormone Concentrations and Hormonal Receptor Status Among Postmenopausal Chinese Women With Breast Cancer: An Observational Study[J]. FRONTIERS IN ONCOLOGY,2022,12. |
| APA | Jiang, Chuner.,Wu, Peng.,He, Xiangming.,Ni, Jianfen.,Ding, Xiaowen.,...&Zou, Dehong.(2022).Associations Between Serum Reproductive Hormone Concentrations and Hormonal Receptor Status Among Postmenopausal Chinese Women With Breast Cancer: An Observational Study.FRONTIERS IN ONCOLOGY,12. |
| MLA | Jiang, Chuner,et al."Associations Between Serum Reproductive Hormone Concentrations and Hormonal Receptor Status Among Postmenopausal Chinese Women With Breast Cancer: An Observational Study".FRONTIERS IN ONCOLOGY 12(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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