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A TiO2-based bioprobe enabling excellent SERS activity in the detection of diverse circulating tumor cells

文献类型：期刊论文

作者Xu, Yanping1,2,3,4,5; Lin, Jie2,3,4; Wu, Xiaoxia1,2,3,4; Xu, Xiawei2,3,4; Zhang, Dinghu1,2,3,4; Xie, Yujiao2,3,4; Pan, Ting1; He, Yiwei1,5; Wu, Aiguo2,3,4; Shao, Guoliang1
刊名JOURNAL OF MATERIALS CHEMISTRY B
出版日期2022-04-11
ISSN号2050-750X
DOI10.1039/d2tb00464j
通讯作者Lin, Jie(linjie@nimte.ac.cn) ; Wu, Aiguo(aiguo@nimte.ac.cn) ; Shao, Guoliang(shaogl@zjcc.org.cn)
英文摘要Circulating tumor cells (CTCs) can be the seeds of tumor metastasis and are closely linked to cancer-related death. Fast and effective detection of CTCs is important for the early diagnosis of cancer and the evaluation of micrometastasis. However, the extreme rarity and heterogeneity of CTCs in peripheral blood make sensitive detection of CTCs a big challenge. In this paper, a TiO2-based surface-enhanced Raman scattering (SERS) bioprobe is reported for the first time with outstanding ultrasensitive specificity, excellent stability of the signal, and good biocompatibility for the detection of CTCs. The TiO2 NPs were encoded with alizarin red (AR) and functionalized with reduced bovine serum protein (rBSA) and folic acid (FA). The limit of detection (LOD) for 4-mercaptobenzoic acid (4-MBA) and AR molecules adsorbed on the TiO2 SERS substrate is 5 x 10(-7) M. The designed TiO2-based SERS bioprobe can be effectively utilized in detecting four diverse types of cancer cells in rabbit blood, which shows good sensitivity of the SERS detection technology. Finally, precise targeting of CTCs based on the SERS bioprobe with the function of fluorescence imaging is also confirmed by the fluorescence colouration test. This work offers a novel strategy for CTC detection and the development of non-noble metal semiconductor-based SERS platforms for tumor diagnosis.
WOS关键词ENHANCED RAMAN-SCATTERING ; CHARGE-TRANSFER ; CTC DETECTION ; LABEL-FREE ; NANOPARTICLES ; CAPTURE ; CANCER ; FOLATE
资助项目National Natural Science Foundation of China[52002380] ; National Natural Science Foundation of China[32025021] ; National Natural Science Foundation of China[31971292] ; National Natural Science Foundation of China[51873225] ; Zhejiang Province Key Research Project[2019C03058] ; China Postdoctoral Science Foundation[2021M692872] ; Zhejiang Province Financial Supporting[2020C03110] ; Zhejiang Province Financial Supporting[LQ20E020003] ; 2025 project in Ningbo City[2020Z094] ; Ningbo 3315 Innovative Teams Program[2019A-14-C]
WOS研究方向Materials Science
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:000787857500001
资助机构National Natural Science Foundation of China ; Zhejiang Province Key Research Project ; China Postdoctoral Science Foundation ; Zhejiang Province Financial Supporting ; 2025 project in Ningbo City ; Ningbo 3315 Innovative Teams Program
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/131468]  
专题中国科学院合肥物质科学研究院
通讯作者Lin, Jie; Wu, Aiguo; Shao, Guoliang
作者单位1.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Dept Radiol,Canc Hosp,Zhejiang Canc Hosp, Hangzhou 310022, Peoples R China
2.Chinese Acad Sci, Cixi Inst Biomed Engn, Key Lab Magnet Mat & Devices, Base Biomed Mat Technol & Applicat, Ningbo 315201, Peoples R China
3.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Zhejiang Engn Res Ctr Biomed Mat, Ningbo 315201, Peoples R China
4.Adv Energy Sci & Technol Guangdong Lab, Huizhou 516000, Peoples R China
5.Zhejiang Chinese Med Univ, Clin Coll 2, Hangzhou 310053, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Yanping,Lin, Jie,Wu, Xiaoxia,et al. A TiO2-based bioprobe enabling excellent SERS activity in the detection of diverse circulating tumor cells[J]. JOURNAL OF MATERIALS CHEMISTRY B,2022.
APA Xu, Yanping.,Lin, Jie.,Wu, Xiaoxia.,Xu, Xiawei.,Zhang, Dinghu.,...&Shao, Guoliang.(2022).A TiO2-based bioprobe enabling excellent SERS activity in the detection of diverse circulating tumor cells.JOURNAL OF MATERIALS CHEMISTRY B.
MLA Xu, Yanping,et al."A TiO2-based bioprobe enabling excellent SERS activity in the detection of diverse circulating tumor cells".JOURNAL OF MATERIALS CHEMISTRY B (2022).

入库方式： OAI收割

来源：合肥物质科学研究院

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