Structural and functional regulations by a disulfide bond designed in myoglobin like human neuroglobin
文献类型：期刊论文
| 作者 | Sun, Li-Juan1; Yuan, Hong2,3; Yu, Lu4; Gao, Shu-Qin1,5; Wen, Ge-Bo1,5; Tan, Xiangshi2,3; Lin, Ying-Wu1,5 |
| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2022-05-12 |
| 卷号 | 58 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/d2cc01753a |
| 通讯作者 | Lin, Ying-Wu(ywlin@usc.edu.cn) |
| 英文摘要 | An artificial disulfide bond (Cys46-Cys61) was designed in the heme distal site of myoglobin, which regulates the conformation of the heme distal His64 and the protein reactivity, as confirmed by X-ray crystallography, EPR, and kinetic UV-vis studies. This study shows the successful design of a disulfide bond with suitable positions in globins, conferring a structure and function like those of the native human neuroglobin. |
| WOS关键词 | SPERM-WHALE MYOGLOBIN ; REDUCTASE-ACTIVITY ; CRYSTAL-STRUCTURE ; HEME-PROTEINS ; NITRIC-OXIDE ; FINE-TUNES ; DYNAMICS ; LIGAND ; CYTOGLOBIN ; BINDING |
| 资助项目 | National Natural Science Foundation of China[21977042] ; National Natural Science Foundation of China[32171270] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000787364900001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131476]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Lin, Ying-Wu |
| 作者单位 | 1.Univ South China, Hengyang Med Coll, Hengyang 421001, Peoples R China 2.Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China 3.Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China 4.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China 5.Univ South China, Key Lab Prot Struct & Funct Univ Hunan Prov, Hengyang 421001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Li-Juan,Yuan, Hong,Yu, Lu,et al. Structural and functional regulations by a disulfide bond designed in myoglobin like human neuroglobin[J]. CHEMICAL COMMUNICATIONS,2022,58. |
| APA | Sun, Li-Juan.,Yuan, Hong.,Yu, Lu.,Gao, Shu-Qin.,Wen, Ge-Bo.,...&Lin, Ying-Wu.(2022).Structural and functional regulations by a disulfide bond designed in myoglobin like human neuroglobin.CHEMICAL COMMUNICATIONS,58. |
| MLA | Sun, Li-Juan,et al."Structural and functional regulations by a disulfide bond designed in myoglobin like human neuroglobin".CHEMICAL COMMUNICATIONS 58(2022). |
入库方式： OAI收割
来源：合肥物质科学研究院
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