中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
Preoperative chemotherapy combined with para-aortic lymph node dissection has clinical value in the treatment of gastric cancer with para-aortic lymph node metastases

文献类型：期刊论文

作者Yu, Pengcheng2; Hu, Can3; Wang, Yi2; Bao, Zhehan2; Zhang, Ruolan3; Cao, Mengxuan1; Zhang, Yanqiang4; Cheng, Xiangdong4; Xu, Zhiyuan4
刊名BMC SURGERY
出版日期2022-11-20
卷号22
关键词Gastric cancer Para-aortic lymph node dissection Para-aortic lymph node metastasis Chemotherapy
DOI10.1186/s12893-022-01844-0
通讯作者Zhang, Yanqiang(zyq201003@163.com) ; Cheng, Xiangdong(chengxd@zjcc.org.cn) ; Xu, Zhiyuan(xuzy@zjcc.org.cn)
英文摘要Background Lymph node metastases often occur in advanced gastric cancer, with some patients presenting with metastases in the para-aortic lymph nodes. There are persistent Controversies about the benefit of para-aortic lymph node dissection (PAND). Our purpose is to probe whether PAND following preoperative chemotherapy had any clinical significance in individuals with PALNs in gastric cancer. Material and methods To retrospectively analyze the clinical data of 86 gastric cancer patients (40 in the D2 + PAND group and 46 in the D2 group) who attended the abdominal surgery department of Zhejiang Cancer Hospital between September 1, 2008, and July 30, 2018. Results In the D2 + PAND group (40 cases), the average number of lymph nodes cleared per case was 4.3 in group 16 (16a2, 16b1), and the postoperative pathology confirmed lymph node positivity in 16 cases, with a metastasis rate of 40%. The median overall survival times were 63 and 34 months for the patients in the D2 + PAND group and D2 group, respectively. The 3-year overall survival (OS) compared to the D2 group (D2 + PAND 69.1% vs. D2 50%, P = 0.012) and a statistically significant difference in 3-year disease-free survival (DFS) (D2 + PAND 69.6% vs. D2 38.3%, P = 0.007). Lymph node dissection extent and recurrence of para-aortic lymph nodes were independent prognostic variables for the patients. The recurrence rate was reduced in the D2 + PAND group compared to the D2 group (D2 + PAND 7.5% vs. D2 26.1%, p = 0.023). Conclusions For patients with gastric cancer whose imaging suggests metastasis in the para-aortic lymph nodes, preoperative chemotherapy combined with PAND is an effective and safe treatment that may benefit patient survival.
WOS关键词NEOADJUVANT CHEMOTHERAPY ; PHASE-II ; D2 GASTRECTOMY ; LYMPHADENECTOMY ; CISPLATIN ; SURGERY ; S-1
资助项目National Natural Science Foundation of China[81973634] ; Program of Zhejiang Provincial TCM Sci-tech Plan[2019ZZ010] ; Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer[JBZX-202006]
WOS研究方向Surgery
语种英语
出版者BMC
WOS记录号WOS:000885837300001
资助机构National Natural Science Foundation of China ; Program of Zhejiang Provincial TCM Sci-tech Plan ; Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/131652]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Yanqiang; Cheng, Xiangdong; Xu, Zhiyuan
作者单位1.Wenzhou Med Univ, Wenzhou 325035, Peoples R China
2.Chinese Med Univ, Clin Med Coll Zhejiang 1, Hangzhou 310053, Peoples R China
3.Chinese Med Univ, Clin Med Coll Zhejiang 2, Hangzhou 310053, Peoples R China
4.Chinese Acad Sci, Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp,Inst Basic Med & Canc IBMC, Banshan Rd 1, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Pengcheng,Hu, Can,Wang, Yi,et al. Preoperative chemotherapy combined with para-aortic lymph node dissection has clinical value in the treatment of gastric cancer with para-aortic lymph node metastases[J]. BMC SURGERY,2022,22.
APA Yu, Pengcheng.,Hu, Can.,Wang, Yi.,Bao, Zhehan.,Zhang, Ruolan.,...&Xu, Zhiyuan.(2022).Preoperative chemotherapy combined with para-aortic lymph node dissection has clinical value in the treatment of gastric cancer with para-aortic lymph node metastases.BMC SURGERY,22.
MLA Yu, Pengcheng,et al."Preoperative chemotherapy combined with para-aortic lymph node dissection has clinical value in the treatment of gastric cancer with para-aortic lymph node metastases".BMC SURGERY 22(2022).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。